Molecular Imaging in Cancer Biology Training Program

项目摘要 T32“癌症生物学分子成像”计划（T32 MICB）的中心使命是开发 新的分子成像方法，技术和平台，将加速人类的理解， 癌症生物学作为设计治愈性癌症治疗方案的基础， 诊断、预后和治疗工具。这一总体目标将在三个关键领域的支持下实现。 主题：（1）“成像基础生物学”，（2）“成像新模型系统”，（3）“成像技术 发展”。这个T32 MICB研究组合位于各种学科的交叉点-从 基础科学，包括化学和物理学，结构生物学，药物开发，细胞生物学， 发育生物学到癌症生物学、侵袭和转移，以及应用学科，包括 药理学、纳米技术、放射化学、工程学和医学。基础知识关于 癌症的生物学已经蓬勃发展，但将基础科学发现转化为临床进展 可能是缓慢和低效的;分子成像可以显着加速这一过程， 一群精通分子成像各个方面的基础科学家对这项工作的成功至关重要。 奋进。为T32 MICB选择的教师反映了广泛的专业知识， 在各自的成像领域的领导者。他们资金充足，有独立的R 01（癌症相关）或 R 01类研究支持（例如，R35或HHMI）。为了确保受训人员（五个博士后名额和一个 博士前插槽每年）有一个全面的培训经验（包括弹性和福祉）， 为独立职业做准备，我们的初步设计是基于一个为期三年的培训计划， 包括博士后研究员和博士前研究生实习生。在进入T32 MICB之前 在培训过程中，受训人员将被告知T32微型战斗机的使命 该计划旨在培养具有癌症生物学进展专业知识的科学家 和成像技术，在一个尊重和参与的文化中。此外，学员将被告知 关于计划期间的预期成就，并将不断评估其进展， 基准。

PROJECT ABSTRACT The central mission of the T32 “Molecular Imaging in Cancer Biology” program (T32 MICB) will be to develop novel molecular imaging methods, technologies, and platforms that will accelerate the understanding of human cancer biology as a basis for designing curative cancer therapeutic regimens as well as cutting-edge diagnostic, prognostic, and therapeutic tools. This overall goal will be achieved under the auspices of three key themes: (1) “Imaging Fundamental Biology,” (2) “Imaging New Model Systems,” and (3) “Imaging Technology Development.” This T32 MICB research portfolio is situated at the intersection of various disciplines—from basic science including chemistry and physics, structural biology, drug development, cell biology, and developmental biology to cancer biology, invasion and metastasis, and applied disciplines, including pharmacology, nanotechnology, radiochemistry, engineering, and medicine. Fundamental knowledge about the biology of cancer has burgeoned, but the translation of basic science discoveries to clinical advancements can be slow and inefficient; molecular imaging can significantly accelerate this process and a well-trained population of basic scientists well-versed in all aspects of molecular imaging is crucial to the success of this endeavor. The faculty preceptors chosen for this T32 MICB reflect the broad range of expertise and are leaders in their respective imaging fields. They are well-funded and have independent R01 (cancer-related) or R01-like research support (e.g., R35 or HHMI). To ensure that the trainees (five post-doctoral slots and one pre-doctoral slot per year) have a full well-rounded training experience (including resilience and well-being) in preparation for independent careers, our initial design is based on a three-year training program for both the postdoctoral fellows and the predoctoral graduate student trainees. Prior to entry into the T32 MICB program and during the program, the trainees will be informed about the mission of the T32 MICB program, which is to produce scientists with specialized knowledge in advances in cancer biology and imaging technology, within a culture of respect and engagement. Furthermore, trainees will be informed about expected achievements during the program and that their progress will be continuously evaluated and benchmarked.