Research Training in Hematology

我们的培训计划汇集了来自八个系的22名教职员工，专注于两个 对血液学和人类疾病具有广泛重要性的领域：血管生物学和干细胞 生物学/血液系统恶性肿瘤。其主要目标是培养多学科的医学博士和博士科学家 在血液学方面进行持续的、独立的研究。申请两个博士后职位 这将从一批杰出的博士和医学博士研究生中选出 威斯康星大学(UW)的课程。需要四个博士后职位来培训研究人员 跟踪参与的临床(医学、儿科)和基础科学(生物医学工程、 生物分子化学、细胞和再生医学、医学微生物学和免疫学、肿瘤学和 病理学)科室。高度互动的培训人员分成三个兴趣小组：血管 生物学/炎症；免疫调节、造血发育/恶性肿瘤；干细胞生物学/骨 骨髓移植。血管生物学方面的专业知识包括微流体、蛋白质组学、细胞迁移、 细胞外基质生物学，炎症细胞机制，嗜酸性粒细胞生物学，血管建模 以及细胞迁移、止血和亲血栓状态的分子方面。血液系统恶性肿瘤/干细胞 细胞生物学是由一个著名的干细胞研究小组领导的。专长包括胚胎(ES)、诱导 多能性(IPSC)与间充质干细胞生物学、正常和异常的表观遗传调控 造血分化；造血、白血病和淋巴细胞中的细胞内信号； 骨髓瘤的免疫治疗、肿瘤免疫学、异基因骨髓移植的临床前模型； 干细胞的临床试验和骨髓成像，以及临床应用。培训机会跨度 基础和临床研究；包括基因组学、蛋白质组学、代谢组学、 微流体学、斑马鱼和小鼠疾病模型以及干细胞移植。我们非常强调 关于临床研究人员的转化性研究和多学科培训。威斯康星大学临床和医学研究所 转化性研究提供临床调查、职业发展和 辅导专业知识。我们的学员在建立研究事业方面有着出色的记录。十五 博士前任命的人现在已经完成了他们的博士学位。其中7人是学院教师或科学家。 职位，三名是行业科学家，两名正在完成高级专科临床培训，一名是 一所师范学院的化学教授。24名博士后实习生完成了他们的 在过去的15年中，对该补助金的任命。这些实习生包括11名助理教授，2名 副教授、三名学术科学家、两名行业科学家和两名完成培训的人。大的 合格的候选人人才库，我们培训师出色的指导记录，机构承诺，以及广泛的 各种科学专业知识都有助于我们的学员在科学领域取得成功。

Our training program brings together twenty-two faculty members from eight Departments to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal is to train M.D. and Ph.D. scientists in a multi-disciplinary environment to do sustained, independent research in hematology. Two predoctoral positions are requested that will be filled from an outstanding pool of Ph.D. and M.D.-Ph.D. students in the well-established graduate programs at the University of Wisconsin (UW). Four postdoctoral positions are requested to train research track candidates from participating clinical (Medicine, Pediatrics) and basic science (Biomedical Engineering, Biomolecular Chemistry, Cell and Regenerative Medicine, Medical Microbiology & Immunology, Oncology, and Pathology) departments. The highly interactive training faculty cluster into three interest groups: vascular biology/inflammation; immune regulation, hematopoietic development/malignancy; and stem cell biology/bone marrow transplantation. Expertise in vascular biology includes microfluidics, proteomics, cellular migration, extracellular matrix biology, cellular mechanisms of inflammation, eosinophil biology, modeling of blood vessels and cell migration, molecular aspects of hemostasis and thrombophilic states. Hematologic malignancy/stem cell biology is led by a prominent group of stem cell investigators. Expertise includes embryonic (ES), induced pluripotent (iPSC) and mesenchymal stem cell biology, epigenetic regulation of normal and abnormal hematopoietic differentiation; intracellular signaling in hematopoiesis, leukemogenesis, and lymphocytes; immunotherapy of myeloma, tumor immunology, preclinical models of allogeneic bone marrow transplant; clinical trials and bone marrow imaging, and clinical applications of stem cells. Training opportunities span basic and clinical investigation; including cutting-edge technologies in genomics, proteomics, metabolomics, microfluidics, zebrafish and murine disease models, and stem cell transplantation. A strong emphasis is placed on translational research and multidisciplinary training of clinical investigators. The UW Institute for Clinical and Translational Research offers didactic and degree programs in clinical investigation, career development, and mentoring expertise. Our trainees have an excellent record of establishing research careers. Fifteen predoctoral appointees have now completed their Ph.D. degrees. Seven are in academic faculty or scientist positions, three are industry scientists, two are completing advanced subspecialty clinical training, one is a chemistry professor at a teaching college. Twenty-four post-doctoral trainees have completed their appointments on the grant in the past fifteen years. These trainees include eleven assistant professors, two associate professors, three academic scientists, two industry scientists, and two completing training. The large pool of qualified candidates, outstanding mentorship record of our trainers, institutional commitment, and broad range of scientific expertise all contribute to successful careers in science for our trainees.