Visual-Motor Integration

项目描述（申请人提供）：本项目旨在了解人类额叶和顶叶的视觉运动整合机制。控制眼睛和肢体位置的大脑系统之间的相互作用有助于视觉-运动整合。凝视影响非人类灵长类动物大脑中许多部位的感觉和运动处理;关于凝视如何调节人类感觉运动处理的知之甚少。确定凝视和肢体运动控制如何在顶叶和额叶区域相互作用，对于理解有目的的视觉-运动整合至关重要。 我们将使用功能性磁共振成像和脑电图来测量额叶和顶叶的处理基础的凝视和手部运动的相互作用。我们最近发现了人类顶叶和额叶区域存在凝视增益场;该项目将使用增益场的变化和凝视引起的手部运动脑反应调制来理解视觉输入，凝视位置和手部运动的整合，以达到自愿行动的顶叶-额叶组织模型。 该项目有三个目标：第一，在人类顶叶和额叶中发展和维持凝视增益场的原则是什么？我们将研究组织和变化的增益领域和凝视诱导调制的手部运动表征的信息传递从顶叶到额叶的视觉动作流。第二，当信息从顶叶流向额叶时，结合视觉输入和手部运动时，是否需要凝视和手部运动之间的空间兼容性？为了这个目的，我们将调查是否眼-手的空间兼容性和手臂效应器的选择有关键作用，在发展增益领域。第三，顶叶和额叶皮层中与手臂运动相关的区域使用什么坐标系？在这些实验中，我们将测试顶叶和额叶区域是否使用眼睛，头部，身体或世界为中心的坐标框架时，整合眼睛的位置与手臂运动。总的来说，这些实验将确定凝视和手臂位置之间的空间兼容性是否代表了构建调节眼睛和手部运动的额叶和顶叶区域的激活和功能连接模式所需的关键监管特征。这些结果将应用于感觉运动整合的模型，以及动态大脑表征如何被创建和修改，特别是关于运动计划是否在顶叶形成，然后传递到额叶皮层，或者顶叶将基本信息传递到额叶结构进行最终规划。

DESCRIPTION (provided by applicant): This project aims to understand mechanisms of visual-motor integration in human frontal and parietal lobes. Interactions among brain systems controlling eye and limb position contribute to visual-motor integration. Gaze influences sensory and motor processing at many brain sites in non-human primates; significantly less is known about how gaze regulates human sensory-motor processing. Determining how gaze and limb motor control interact in parietal and frontal areas seems essential to understand purposeful visual-motor integration. We will use functional MRI and electroencephalography to measure frontal and parietal processing underlying gaze and hand movement interactions. We have recently discovered the existence of gaze gain fields in human parietal and frontal areas; the project will use changes in gain fields and gaze-induced modulation of hand movement brain responses to understand integration of visual input, gaze position and hand movements to arrive at a model of parietal-frontal organization for voluntary action. The project has three aims: First, what are the principles for developing and maintaining gaze gain fields in human parietal and frontal lobes? We will investigate organization and changes in gain fields and gaze-induced modulation of hand movement representations as information passes from parietal to frontal lobe in the vision to action stream. Second, is spatial compatibility between gaze and hand movements required when combining visual input and hand movements as information flows from human parietal to frontal areas? For this aim, we will investigate whether eye-hand spatial compatibility and choice of arm effector have key roles in developing gain fields. Third, what coordinate system do arm movement related areas in parietal and frontal cortex use? In these experiments, we will test whether parietal and frontal areas use eye-, head-, body- or world-centered coordinate frameworks when integrating eye position with arm movements. Collectively, the experiments will determine whether spatial compatibility among location of gaze and arm positions represents a key regulatory feature needed to construct activation and functional connectivity patterns of frontal and parietal areas that mediate eye and hand movements. The results will have application to models of sensory motor integration and how dynamic brain representations become created and modified, especially regarding whether motor plans are formed in the parietal lobe and then relayed to frontal cortex or alternatively that the parietal lobe relays fundamental information to frontal structures for eventual planning.