Institute for Biogenesis Research: COBRE

描述(由申请人提供)：夏威夷大学马诺阿分校的约翰·A·伯恩斯医学院(JABSOM)正在提交这份申请，以回应美国国立卫生研究院(NIH)的PAR-07-229。凭借卓越生物医学研究中心(Cobre)奖，我们寻求将JABSOM的生物发生研究所(IBR)转变为生殖生物学的跨学科、转化性研究机构。IBR是由夏威夷州和UH Manoa于1999年在JABSOM的解剖和生殖生物学系建立的。它的基本原理是延续由国家科学院院士柳内龙藏博士开创的生殖生物学研究的遗产。Yanagimachi博士和他的团队在生殖生物学方面取得了重大突破，包括卵胞浆内单精子注射(ICSI)的发展、哺乳动物体外受精(IVF)的基本原理、哺乳动物重复克隆的首次演示以及ICSI介导的转基因小鼠。我们建议通过合作、跨学科指导和创建转基因核心来扩展IBR。这种扩展将建立在IBR杰出的基础科学的基础上，同时将其研究重点引导到生殖生物学的跨学科、转译研究上。IBR的研究重点在于哺乳动物胚胎发生的早期分子事件及其对后期发育阶段的影响。通过与临床妇产科和太平洋试管受精研究所的合作，我们将支持旨在促进生殖科学并通过最新的分子、细胞和微技术减少儿童不孕不育和出生缺陷的翻译项目，其中许多技术是在密歇根大学开发的。我们力求通过以下具体目标实现这一目标。在具体目标1中，我们将把生物发生研究所(IBR)转变为一个具有国家竞争力的、跨学科的、翻译的生殖生物学研究中心。具体目标2的重点将是通过跨学科研究和职业发展活动聘请资深科学家指导初级调查人员，从而推动生殖和不孕不育的科学研究并提高机构能力。在具体目标3中，我们将通过利用该中心的专业知识来开发转基因动物核心，从而提高机构能力，这将使整个大学的研究人员受益。IBR Cobre将通过增强校园内可供研究人员使用的核心资源，为密歇根大学马诺阿分校的基础设施做出贡献，并将支持有才华的初级教员在进行旨在产生与生殖健康相关的数据的创新基础、临床和翻译研究时走向独立。

DESCRIPTION (provided by applicant): The John A. Burns School of Medicine (JABSOM) at the University of Hawaii at Manoa (UH Manoa) is submitting this application in response to National Institutes of Health (NIH) PAR-07-229. With a Center of Biomedical Research Excellence (COBRE) award, we seek to transform JABSOM's Institute for Biogenesis Research (IBR) into an interdisciplinary, translational research institute for reproductive biology. The IBR was established in 1999 by the State of Hawaii and UH Manoa in JABSOM's Department of Anatomy & Reproductive Biology. Its rationale was to continue the legacy of reproductive biology research pioneered by National Academy member Dr. Ryuzo Yanagimachi. Dr. Yanagimachi and his team produced major breakthroughs in reproductive biology, including the development of intracytoplasmic sperm injection (ICSI), the principles underlying in vitro fertilization (IVF) in mammals, the first demonstration of repetitive mammalian cloning, and ICSI-mediated transgenic mice. We propose expansion of the IBR through collaboration, interdisciplinary mentoring, and creation of a transgenic Core. Such expansion will build upon the IBR's foundation of outstanding basic science while directing its research emphasis toward interdisciplinary, translational research in reproductive biology. The IBR's research focus lies in early molecular events in mammalian embryogenesis and their effects on later stages of development. Through partnership with the clinical Department of Obstetrics and Gynecology and Pacific IVF Institute, we will support translational projects designed to advance the science of reproduction and reduce infertility and birth defects for children through the latest molecular, cellular, and micro-techniques, many of which were developed at UH. We seek to accomplish this objective through the following specific aims. In Specific Aim 1, we will transform the Institute for Biogenesis Research (IBR) into a nationally competitive, interdisciplinary, translational reproductive biology research center. The focus of Specific Aim 2 will be to advance the science of reproduction and infertility and improve institutional capacity by engaging senior scientists to mentor junior investigators through interdisciplinary research studies and career development activities. In Specific Aim 3 we will improve institutional capacity by drawing upon the center's expertise to develop a transgenic animal Core that will benefit investigators throughout the university. The IBR COBRE will contribute to infrastructure at UH Manoa by enhancing Core resources available for investigators across campus, and will support talented junior faculty toward independence as they conduct innovative basic, clinical and translational studies designed to produce data relevant to reproductive health.