Frontiers of NMR Biology

描述(由申请人提供)：本提案请求支持由Michael F.Summers、DorotheKern和David E.Wemmer组织的题为核磁共振生物学前沿的Keystone研讨会，该会议将于2011年1月8日至13日在蒙大拿州的Big Sky举行。核磁共振波谱现在是一种成熟的工具，用于确定小到中等大小的生物大分子的结构。然而，通过最近的方法学进步，包括将核磁共振与计算、X射线结晶学、低温电子显微镜和单分子方法相结合的方法的发展，范围正在扩大。这些都导致了对结构、动力学和机制的前所未有的洞察，甚至在大系统中也是如此，使核磁共振成为研究大分子功能的主要工具。本次研讨会将重点介绍核磁共振光谱学的最新技术进展，以及使用这些方法所取得的最新生物功能发现。重点将放在挑战当前技术的系统上，包括高分子量、膜蛋白、折叠和动力学、瞬时状态和药物发现。此外，专题讨论会将提供一个论坛，讨论巩固最佳方法的需要和努力，以及生物核磁共振的最新进展和新趋势。 与公共健康相关：生物分子核磁共振领域继续以高速度发展。过去几年出现的新技术现在为生物功能的折叠途径和机制提供了前所未有的洞察力。2011年关于核磁共振生物学前沿的Keystone研讨会会议将重点介绍核磁共振光谱学的最新技术进步，以及使用这些方法取得的最新生物功能发现，以及它们在广泛的生物学问题上的应用。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Frontiers of NMR Biology, organized by Michael F. Summers, Dorothee Kern and David E. Wemmer, which will be held in Big Sky, Montana from January 8 - 13, 2011. Nuclear magnetic resonance (NMR) spectroscopy is now a well-established tool for determining structures of small to moderate size biomacromolecules. The horizon is expanding, however, through recent methodological advances, including the evolution of approaches that combine NMR with computational, X-ray crystallographic, cryo-electron microscopic, and single molecule methodologies. These have led to unprecedented insights into structure, dynamics, and mechanisms, even in large systems, making NMR a premier tool for studying macromolecular function. This symposium will highlight the latest technological advances in NMR spectroscopy, as well as recent bio-functional discoveries made using these approaches. Emphasis will be placed on systems that challenge the current technology, including high- molecular weights, membrane proteins, folding and dynamics, transient states, and drug discovery. In addition, the symposium will provide a forum for discussions on the needs and efforts to consolidate the best approaches, and on the latest advances and new trends in biological NMR. PUBLIC HEALTH RELEVANCE: The field of biomolecular NMR continues to develop at a high rate. New technologies have emerged over the past few years that now provide unprecedented insights into the folding pathways and mechanisms of biological function. The 2011 Keystone Symposia meeting on Frontiers of NMR Biology will highlight the latest technological advances in NMR spectroscopy, as well as recent bio-functional discoveries made using these approaches, as well as their application to a broad range of biological problems.