B Cells: New Insights into Normal versus Dysregulated Function

描述(由申请人提供)：本提案请求支持将于2011年4月12-17日在加拿大不列颠哥伦比亚省惠斯勒举行的题为B细胞：对正常与失调功能的新见解的Keystone研讨会，该会议由David J.Rawling、France E.Lund、Stuart G.Tangye和John G.Monroe组织。B淋巴细胞通过一系列高度协调的过程在宿主抵抗感染中发挥关键作用，这些过程包括细胞归巢、抗原识别、抗体分泌、抗原呈递和细胞因子释放。为了完成这些无数的功能，B细胞必须通过一系列复杂的初级和次级发育、稳态和激活触发的检查点。这些检查点根据局部微环境、细胞-细胞相互作用以及与致病或非致病生物的相互作用，决定随机的和分子导向的事件。在这一发育级联中的早期事件促进了多样化的B细胞抗原受体谱系的产生，这对于生存和进入下游效应者群体都是必不可少的。同时，在导致特定克隆丢失或扩展的多个步骤中测试该曲目的自我反应性。这些复杂过程的失调可能会导致免疫缺陷、自身免疫或恶性疾病。2011年关于B细胞的Keystone研讨会的总体目标是强调最近关于正常和异常B细胞发育和功能的研究，并尽可能强调来自人类研究的数据。 公共卫生相关性：B淋巴细胞，或B细胞，通过协调先天和获得性免疫反应，在控制细菌、病毒和寄生虫病原体方面发挥关键作用。B细胞功能失调可导致免疫缺陷、自身免疫或恶性疾病。关于B细胞的Keystone研讨会会议将聚集来自涉及研究B淋巴细胞生物学的多个学科的研究人员，分享数据，讨论研究挑战，并进行合作，以便为如何利用这些信息为治疗多种重要的人类疾病提供洞察力。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled B Cells: New Insights into Normal versus Dysregulated Function, organized by David J. Rawlings, Frances E. Lund, Stuart G. Tangye and John G. Monroe, which will be held in Whistler, British Columbia, Canada from April 12 - 17, 2011. B lymphocytes play crucial roles in host defense against infection via a series of highly coordinated processes that include cell homing, antigen recognition, antibody secretion, antigen presentation, and cytokine release. To accomplish these myriad functions, B cells must maneuver through a complex series of primary and secondary developmental, homoeostatic, and activation-triggered checkpoints. These checkpoints dictate stochastic and molecularly directed events dependent upon local micro-environments, cell-cell interactions, and interactions with pathogenic or non-pathogenic organisms. Early events in this developmental cascade promote the generation of a diverse B cell antigen receptor repertoire that is essential for both survival and entry into downstream effector populations. In parallel, this repertoire is tested for self-reactivity at multiple steps leading to either loss or expansion of specific clones. Dysregulation of these complex processes can lead, alternatively, to immunodeficiency, autoimmunity, or malignant disease. The overall goal of the 2011 Keystone Symposia meeting on B Cells is to highlight recent studies of normal versus abnormal B cell development and function with an emphasis, whenever possible, to data from studies of humans. PUBLIC HEALTH RELEVANCE: B lymphocytes, or B cells, play a critical role in controlling bacterial, viral, and parasitic pathogens via orchestration of both innate and adaptive immune responses. Dysregulated B cell function can lead to immunodeficiency, autoimmunity, or malignant disease. The Keystone Symposia meeting on B Cells will gather investigators from multiple disciplines involved in studying B lymphocyte biology to share data, discuss research challenges, and collaborate in order to provide insight into how to utilize this information for therapeutic benefit in multiple important human disorders.