NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses

描述（由申请人提供）： 摘要 PI：ROBERTSON，ANDREW D 项目：1 R13 AI 091292 -01标题：NK和NKT细胞生物学：先天应答的特异性和重复性登录号：3255538 ================== 注意事项：本摘要摘自应用程序，未经SRA验证。当应用程序扫描过程出现问题时，提取的文本可能不正确或不完整。 ================== 该提案请求支持由James P. Di Santo、Eleanor M.莱利和米切尔克罗嫩伯格，这将是在布雷肯里奇，科罗拉多从2011年1月9日至14日举行。在过去的十年里，我们在先天免疫方面的知识基础已经爆炸式增长，我们对先天免疫机制的理解将很快影响临床。尽管如此，我们仍然有很多关于NK细胞和NKT细胞如何形成先天性和适应性免疫反应的知识。本次会议将解决与这两个专门的先天淋巴细胞群体的生物学作用有关的问题，将NK和NKT细胞专家聚集在一起，讨论他们最新的前沿成果，主题包括NK/NKT发展; NK/NKT细胞-配体识别; NK/NKT活化和“串扰”;以及NK/NKT细胞作为炎症性疾病，感染和癌症免疫反应的效应器和调节器的作用。NK细胞和NKT细胞生物学家之间的这种“对抗”应该促进一个活跃的论坛，讨论和辩论NK/NKT细胞反应的特异性和冗余性，并有望导致新的合作，以帮助我们进一步了解这些重要的先天介质的生物学作用。事实上，这次会议是唯一一次将世界领先的NK和NKT细胞生物学专家聚集在一个论坛上的国际会议，该论坛专门致力于了解这两种先天淋巴细胞亚群之间的“串扰”。本次会议将解决许多有关的基本机制参与激活和调节免疫反应的传染性病原体的问题。此外，了解NK和NKT细胞生物学具有广泛的意义，因此多个不同的全体会议将致力于这两种细胞类型的研究，包括从信号传导和发育到感染，自身免疫和癌症背景下免疫反应的整个器官研究。

DESCRIPTION (provided by applicant): Abstract PI: ROBERTSON, ANDREW D Project: 1R13AI091292-01 Title: NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses Accession Number: 3255538 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== This proposal requests support for a Keystone Symposia meeting entitled NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses, organized by James P. Di Santo, Eleanor M. Riley and Mitchell Kronenberg, which will be held in Breckenridge, Colorado from January 9 - 14, 2011. Our knowledge base in innate immunity has exploded over the past decade, and our understanding of innate immune mechanisms will soon impact in the clinics. Nevertheless, we still have much to learn about how NK cells and NKT cells shape innate and adaptive immune responses. This meeting will address issues related to the biological roles of these two specialized innate lymphocyte populations by bringing together NK and NKT cell experts to discuss their latest cutting-edge results on topics including NK/NKT development; NK/NKT cell- ligand recognition; NK/NKT activation and "crosstalk"; and roles for NK/NKT cells as both effectors and regulators of the immune response in inflammatory disease, infection and cancer. This "confrontation" between NK cell and NKT cell biologists should promote a lively forum for discussion and debate about the specificity and redundancy of NK/NKT cell responses, and can hopefully lead to new collaborations to help advance our understanding of the biological roles of these important innate mediators. In fact, this meeting is the only international meeting that brings together the world's leading experts on NK and NKT cell biology in a forum that is uniquely devoted to understanding the "crosstalk" between these two innate lymphocyte subsets. This meeting will address many questions related to fundamental mechanisms involved in the activation and regulation of immune responses to infectious pathogens. Moreover, understanding NK and NKT cell biology has broad implications, and therefore multiple, diverse plenary sessions will be devoted to the study of these two cell types, encompassing everything from signaling and development to whole organ studies of immune responses in the context of infection, autoimmunity and cancer.