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Kinetochore Interaction with Centromere Chromatin in human cells

Kinetochore Interaction with Centromere Chromatin in human cells
着丝粒与人体细胞中着丝粒染色质的相互作用
批准号:
8157701
负责人:
YAMINI P DALAL
金额:
$18.97万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
我们的目标是剖析着丝粒蛋白结合基因组中的着丝粒染色质的机制,并为功能性着丝粒创造基础。自2010年新博士后项目启动以来,这项工作正在进行中。与人类多能细胞(hPSC)研究者Amander Clark(UCLA)合作进行了一项单独的研究,我们发现着丝粒蛋白储备在细胞分化和染色体损伤传感中发挥作用。这项工作发表在Human Mol上。遗传学2010年8月由于最近关于在联邦资助的项目中使用hPSC的裁决,后续项目被暂停。
英文摘要
Our goal is to dissect the mechanism by which kinetochore proteins binds the centromeric chromatin in the genome and creates the basis for a functional centromere. Since the project started by new postdoctoral associate in 2010, this work is in progress. A separate study was conducted in collaboration with a human pluripotent cell (hPSC) investigator Amander Clark (UCLA), where we discovered that the centromeric protein reserve plays a role in cell differentiation and in chromosome damage sensing. This work was published in Human Mol. Genetics August 2010. The follow up project was suspended due to the recent ruling on the use of hPSC in federally funded projects.
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