Nuclear Receptors: Full Throttle

 描述（由申请人提供）：支持被要求为一个基石研讨会会议，题为核受体：全油门，由卡罗尔A。作者：Jennifer K. Richer和Karen E.努森会议将于2016年1月10日至15日在犹他州雪鸟举行。核受体（NR）代表了一个大的超家族的配体依赖性转录因子的“传感器”的一组不同的脂溶性激素，维生素和膳食脂质。NR协调对正常稳态至关重要的遗传反应程序，并且是生殖，发育，代谢和免疫功能所必需的。出于这个原因，NR已经被研究了超过30年，作为治疗广泛疾病的药物的有希望的靶标，所述疾病包括癌症、糖尿病和其他内分泌或代谢紊乱、肥胖症、心血管疾病、高血压、炎症和胆汁淤积。对NRs的研究已经导致了许多成功的致命疾病治疗方法，这些方法提高了寿命和生活质量。然而，仍然存在重大障碍，需要进一步详细了解 由核受体调控的主要基因调控网络，这些网络在正常相对于疾病前和疾病状态下的差异，以及与靶向组织特异性效应（以减少副作用）和规避耐药机制相关的复杂问题。因此，进一步深入了解NR的全方位功能以及与共调节分子和信号传导途径的相互作用对于涉及NR在健康和疾病中的组合方法以及下一代疗法的开发是必要的。本次会议将汇集我们的领先科学家，包括高级和初级研究人员及其学员，从学术，临床和制药环境，展示最新的科学，突出创新和新兴技术的使用，探索新的方向，并在NR生物学的令人兴奋的领域发展合作和协同努力。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Nuclear Receptors: Full Throttle, organized by Carol A. Lange, Jennifer K. Richer and Karen E. Knudsen. The meeting will be held in Snowbird, Utah from January 10-15, 2016. Nuclear receptors (NRs) represent a large superfamily of ligand-dependent transcription factor "sensors" for a diverse set of fat-soluble hormones, vitamins and dietary lipids. NRs orchestrate genetic response programs critical for normal homeostasis, and are required for reproduction, development, metabolism and immune function. For this reason, NRs have been investigated for over 30 years as promising targets for drugs to treat a broad spectrum of diseases including cancer, diabetes and other endocrine or metabolic disorders, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. Research on NRs has led to numerous successful therapies for deadly diseases that have improved both longevity and quality of life. However, significant hurdles remain that involve further detailed understanding of the major gene regulatory networks regulated by NRs, how these differ in normal relative to pre-disease and disease states, and the complex problems associated with targeting tissue-specific effects (to reduce side effects) and circumventing mechanisms of resistance. Thus, further insight into the full range of NR functions and interactions with co-regulatory molecules and signaling pathways is necessary for combinatorial approaches involving NRs in health and disease, and development of next-generation therapies. This meeting will bring together a diverse array of our leading scientists, including senior and junior investigators and their trainees, from academic, clinical and pharmaceutical settings, to showcase the latest science, highlight the use of innovative and emerging technologies, explore new directions, and develop collaborative and synergistic efforts in the exciting field of NR biology.