Precision medicine for high-risk neuroblastoma
Precision medicine for high-risk neuroblastoma
批准号:
nhmrc : GNT1146817
负责人:
A/Pr Alexander Swarbrick
金额:
$66.0万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --
中文摘要
尽管进行了积极的治疗,但高危神经母细胞瘤患者的存活率仍低于50%。我们最近发现这些预后不良的神经母细胞瘤在一个关键的药物反应通路上有缺陷,称为JNK通路。标准治疗的神经母细胞瘤药物都需要JNK通路来杀死神经母细胞瘤细胞,尽管我们现在已经确定了不需要JNK的替代药物。我们现在计划证明这些药物对JNK通路有缺陷的神经母细胞瘤的疗效。
英文摘要
Despite aggressive treatment, the survival rate for high-risk neuroblastoma patients is below 50%. We recently found that these poor-outcome neuroblastomas have a defect in a key drug response pathway, called the JNK pathway. Standard-of-care neuroblastoma drugs all require the JNK pathway to kill neuroblastoma cells, although we have now identified alternative drugs that do not require JNK. We now plan to demonstrate the efficacy of these drugs in neuroblastomas with a defective JNK pathway.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Discovering new therapeutic strategies for breast cancer at cellular resolution
-
批准号:nhmrc : GNT1161216
-
项目类别:Research Fellowships
-
资助金额:$64.92万
-
财政年份:2019
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?
-
批准号:nhmrc : 1145319
-
项目类别:Project Grants
-
资助金额:$43.05万
-
财政年份:2018
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
How does ROCK ‘education’ of fibroblasts drive neoplastic progression in the breast?
-
批准号:nhmrc : GNT1145319
-
项目类别:Project Grants
-
资助金额:$63.68万
-
财政年份:2018
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
Precision medicine for high-risk neuroblastoma
-
批准号:nhmrc : 1146817
-
项目类别:Project Grants
-
资助金额:$44.63万
-
财政年份:2018
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
Mechanistic and functional analysis of the Id4 proto-oncogene in breast and ovarian cancer
-
批准号:nhmrc : 1107671
-
项目类别:Project Grants
-
资助金额:$47.49万
-
财政年份:2016
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
Mechanistic and functional analysis of the Id4 proto-oncogene in breast and ovarian cancer
-
批准号:nhmrc : GNT1107671
-
项目类别:Project Grants
-
资助金额:$69.4万
-
财政年份:2016
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
The role of interleukin (IL)-27 in the endogenous anti-tumour immune response and the use of an IL-27 agonist as a cancer therapeutic.
-
批准号:nhmrc : 1044967
-
项目类别:Project Grants
-
资助金额:$31.6万
-
财政年份:2013
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
Global characterization of the Src-regulated kinome
-
批准号:nhmrc : 1048550
-
项目类别:Project Grants
-
资助金额:$39.43万
-
财政年份:2013
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
Dissecting the function and therapeutic potential of Hedgehog signaling in breast cancer
-
批准号:nhmrc : 1051348
-
项目类别:Career Development Fellowships
-
资助金额:$30.62万
-
财政年份:2013
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
Cellular and molecular mechanisms of Hedgehog signaling in breast cancer
-
批准号:nhmrc : 1050693
-
项目类别:Project Grants
-
资助金额:$36.8万
-
财政年份:2013
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
The Hedgehog gene as a new drug target for breast cancer
-
批准号:nhmrc : GNT1051348
-
项目类别:Career Development Fellowships
-
资助金额:$43.99万
-
财政年份:2013
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
Regulation of B lymphocyte survival and tumourigenesis by the TRAF2-TRAF3-cIAP signaling complex
-
批准号:nhmrc : 596822
-
项目类别:NHMRC Project Grants
-
资助金额:$29.3万
-
财政年份:2010
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
Dissecting the function of the Hedgehog-Patched pathway in breast cancer progression
-
批准号:nhmrc : 535947
-
项目类别:NHMRC Project Grants
-
资助金额:$40.46万
-
财政年份:2009
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
The role of ID-family HLH proteins in breast cancer
-
批准号:nhmrc : 325646
-
项目类别:Early Career Fellowships
-
资助金额:$22.39万
-
财政年份:2005
-
负责人:A/Pr Alexander Swarbrick
-
依托单位:
国内基金
海外基金
登录
查看更多内容
新型二维/三维双体系癌症研究模型的建立
-
批准号:32070796
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:王霞
-
依托单位:
Chinese Journal of Integrative Medicine
-
批准号:81224004
-
项目类别:专项基金项目
-
资助金额:24.0万元
-
批准年份:2012
-
负责人:徐浩
-
依托单位:
基于新生血管显像研究MSC治疗缺血性脑血管病的转化医学关键问题
-
批准号:81171370
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2011
-
负责人:朱朝晖
-
依托单位:
基于循证医学本体论的临床元数据语言研究
-
批准号:30972549
-
项目类别:面上项目
-
资助金额:24.0万元
-
批准年份:2009
-
负责人:徐维
-
依托单位:
岭南瑶区几种瑶族抗肝炎植物药的化学成分及生物活性研究
-
批准号:20772047
-
项目类别:面上项目
-
资助金额:28.0万元
-
批准年份:2007
-
负责人:岑颖洲
-
依托单位: