Therapeutic targetting of MIF in type 2 diabetes
Therapeutic targetting of MIF in type 2 diabetes
批准号:
nhmrc : 494823
负责人:
A/Pr David Nikolic-Paterson
金额:
$34.65万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
在这项研究中,疾病的小鼠模型将被用来确定促炎分子mif促进胰岛素抵抗和2型糖尿病发展的机制。我们还将测试治疗性阻断MIF是否可以预防2型糖尿病小鼠的疾病进展。对人类患者组织样本的研究将用于证实这些发现与人类的相关性。
英文摘要
In this study, mouse models of disease will be used to determine the mechanisms by which the proinflammatory molecule called MIFpromotes the development of insulin resisitance and type 2 diabetes. We will also test whether therapeutic blockade of MIF can prevent the progression of disease in mice with established type 2 diabetes. Studies on tissue samples obtained from human patients will be used to confirm the human relevance of these findings.
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