Acquisition of a 500 MHz NMR Spectrometer

核磁共振波谱是化学家用来阐明分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振波谱是必不可少的。这项来自化学共享仪器计划的奖项将帮助哈佛大学化学系获得一台高场核磁共振光谱仪。收购将加强的化学研究领域如下：1)利用有机合成低聚糖和多糖酶作为催化剂2)合成的，生物有机的，和药物化学3)新的有机和有机金属反应及其合成方法的发现和发展4)小分子酶模拟物的设计5)碳苷和糖苷的构象分析6)天然产物结构的核磁共振鉴定有机合成7)复杂合成中间体的结构解析。

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectroscopy is essential to chemists who are carrying out frontier research. This award from the Chemistry Shared Instrumentation Program will help the Department of Chemistry at Harvard University to acquire a high-field NMR spectrometer. Among the areas of chemical research that will be enhanced by the acquisition are the following: 1) Organic synthesis of oligo- and polysaccharides using enzymes as catalysts 2) Synthetic, bio-organic, and medicinal chemistry 3) Discovery and development of new organic and organometallic reactions and associated synthesis methodology 4) The design of small molecule enzyme mimics 5) Conformational analysis of C-glycosides and glycosides 6) Natural product structure elucidation by the methods of NMR and organic synthesis 7) Structure elucidation of complex synthetic intermediates.