The mechanical analysis of angiogenic inhibitor TSU68 for the inhibition of liver metastasis and the decision of optimal administration schedule
The mechanical analysis of angiogenic inhibitor TSU68 for the inhibition of liver metastasis and the decision of optimal administration schedule
批准号:
20790948
负责人:
YAMAMOTO Masayoshi
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
The aim of this study was to investigate the inhibitory effect of TSU68 on colon cancer liver metastasis, and to establish the optimal administration schedule with TSU68. In animal model of colon cancer liver metastasis, the expression of CXCL1 in premetastatic liver was significantly decreased by TSU68 treatment. In addition, the amount of interleukin-12 (IL-12) p40 in the portal vein was significantly decreased by TSU68 treatment. These results suggest that TSU68 may modulate the pre-metastatic niche in the target organ through suppression of the inflammatory response, which might be an alternative mechanism used by anti-angiogenic agents.
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大腸癌肝転移におけるCXCL1/CXCR2の関与および血管新生阻害剤TSU68による肝転移制御メカニズム解明
CXCL1/CXCR2参与结直肠癌肝转移及血管生成抑制剂TSU68控制肝转移的机制阐明
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yamamoto, Hirotoshi Kikuchi, Manabu Ohta, Toshiki Kawabata, Yoshihiro Hiramatsu, Kenji Kondo, Megumi Baba, Kinji Kamiya, Tatsuo Tanaka, Masatoshi Kitagawa, Hiroyuki Konno, 山本真義, Masayoshi Yamamoto, 山本真義]
通讯作者:
山本真義
血管新生阻害剤TSU68による肝転移抑制メカニズムの解析
血管生成抑制剂TSU68抑制肝转移的机制分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yamamoto, Hirotoshi Kikuchi, Manabu Ohta, Toshiki Kawabata, Yoshihiro Hiramatsu, Kenji Kondo, Megumi Baba, Kinji Kamiya, Tatsuo Tanaka, Masatoshi Kitagawa, Hiroyuki Konno, 山本真義, Masayoshi Yamamoto, 山本真義, 山本真義, 山本真義, 山本真義, 山本真義]
通讯作者:
山本真義
DOI:
10.1158/0008-5472.can-08-1748
发表时间:
2008-12
期刊:
Cancer research
影响因子:
11.2
作者:
[Masayoshi Yamamoto;H. Kikuchi;M. Ohta;Toshiki Kawabata;Y. Hiramatsu;K. Kondo;Megumi Baba;K. Kamiya;Tatsuo Tanaka;M. Kitagawa;H. Konno]
通讯作者:
Masayoshi Yamamoto;H. Kikuchi;M. Ohta;Toshiki Kawabata;Y. Hiramatsu;K. Kondo;Megumi Baba;K. Kamiya;Tatsuo Tanaka;M. Kitagawa;H. Konno
大腸癌肝転移におけるCXCL1/CXCR2の関与および血管新生阻害剤TSU68による肝転移制御メカニズムの解明
阐明CXCL1/CXCR2参与结直肠癌肝转移及血管生成抑制剂TSU68控制肝转移的机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yamamoto, Hirotoshi Kikuchi, Manabu Ohta, Toshiki Kawabata, Yoshihiro Hiramatsu, Kenji Kondo, Megumi Baba, Kinji Kamiya, Tatsuo Tanaka, Masatoshi Kitagawa, Hiroyuki Konno, 山本真義, Masayoshi Yamamoto, 山本真義, 山本真義]
通讯作者:
山本真義
he role of angiogenic inhibitor TSU68 for the prevention of colon cancer liver metastasis
血管生成抑制剂TSU68预防结肠癌肝转移的作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yamamoto, Hirotoshi Kikuchi, Manabu Ohta, Toshiki Kawabata, Yoshihiro Hiramatsu, Kenji Kondo, Megumi Baba, Kinji Kamiya, Tatsuo Tanaka, Masatoshi Kitagawa, Hiroyuki Konno, 山本真義, Masayoshi Yamamoto, 山本真義, 山本真義, 山本真義, 山本真義, 山本真義, Masayoshi Yamamoto]
通讯作者:
Masayoshi Yamamoto
Optimization of mountaineerer's physical fitness with purposing mountain route
-
批准号:17K01787
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2017
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Self check of physical fitness and training status for safe mountaineering
-
批准号:26350836
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2014
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Construction of dose estimation model for low dose radiation exposurefor residents living around the Semipalatinsk Nuclear Test Site
-
批准号:22404004
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.65万
-
财政年份:2010
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Prevention of mountaineering accidents from the viewpoint of exercise physiology
-
批准号:22500583
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.66万
-
财政年份:2010
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
A Study on Miniaturization of Power Conversion System for Electric Vehicle
-
批准号:22760211
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.58万
-
财政年份:2010
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Behavior of natural radionuclides in high saline undergroundwaters from the deep wells
-
批准号:22510057
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2010
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Toward the solution of radiation dose assessment to the residents living around the former USSR's nuclear test site
-
批准号:19404005
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.4万
-
财政年份:2007
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Reconstruction of Paleoenvironmental Changes using Radionuclides:Uranium and Thorium Isotopes in the Lake Sediments
-
批准号:18510008
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.63万
-
财政年份:2006
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Radioactive contamination around the former Soviet Union's Semipalatinsk nuclear test site and estimation of internal radiation dose for people
-
批准号:16404004
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.23万
-
财政年份:2004
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Development of a new altitude training effective for lowland athletes and altitude climbers of short duration
-
批准号:16500416
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.46万
-
财政年份:2004
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Fundamental studies on variations of uranium and thorium isotopes in Lake bottom sediment core and their application to the paleoenvironmetal changes
-
批准号:16510005
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:2004
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Radiation dose estimation for people in the areas of nuclear disaster : Internal radiation dose estimation for peoples living in the areas surrounding the former Soviet Union's nuclear test site
-
批准号:14403016
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.82万
-
财政年份:2002
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Studies on Speciation of Environmental Plutonium
-
批准号:14580566
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:2002
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Physiological study for improving the success rate of altitude training
-
批准号:12680043
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.73万
-
财政年份:2000
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Study on discrimination of environmental plutonium
-
批准号:11680544
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:1999
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
Environmental Radioactivity Problem around the Former Soviet Union's Semipalatinsk Nuclear Test Site
-
批准号:09680518
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:YAMAMOTO Masayoshi
-
依托单位:
海外基金