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The mechanical analysis of angiogenic inhibitor TSU68 for the inhibition of liver metastasis and the decision of optimal administration schedule

The mechanical analysis of angiogenic inhibitor TSU68 for the inhibition of liver metastasis and the decision of optimal administration schedule
血管生成抑制剂TSU68抑制肝转移的力学分析及最佳给药方案的决定
批准号:
20790948
负责人:
YAMAMOTO Masayoshi
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
The aim of this study was to investigate the inhibitory effect of TSU68 on colon cancer liver metastasis, and to establish the optimal administration schedule with TSU68. In animal model of colon cancer liver metastasis, the expression of CXCL1 in premetastatic liver was significantly decreased by TSU68 treatment. In addition, the amount of interleukin-12 (IL-12) p40 in the portal vein was significantly decreased by TSU68 treatment. These results suggest that TSU68 may modulate the pre-metastatic niche in the target organ through suppression of the inflammatory response, which might be an alternative mechanism used by anti-angiogenic agents.
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会议论文
大腸癌肝転移におけるCXCL1/CXCR2の関与および血管新生阻害剤TSU68による肝転移制御メカニズム解明
CXCL1/CXCR2参与结直肠癌肝转移及血管生成抑制剂TSU68控制肝转移的机制阐明
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yamamoto, Hirotoshi Kikuchi, Manabu Ohta, Toshiki Kawabata, Yoshihiro Hiramatsu, Kenji Kondo, Megumi Baba, Kinji Kamiya, Tatsuo Tanaka, Masatoshi Kitagawa, Hiroyuki Konno, 山本真義, Masayoshi Yamamoto, 山本真義]
通讯作者: 山本真義
血管新生阻害剤TSU68による肝転移抑制メカニズムの解析
血管生成抑制剂TSU68抑制肝转移的机制分析
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Yamamoto, Hirotoshi Kikuchi, Manabu Ohta, Toshiki Kawabata, Yoshihiro Hiramatsu, Kenji Kondo, Megumi Baba, Kinji Kamiya, Tatsuo Tanaka, Masatoshi Kitagawa, Hiroyuki Konno, 山本真義, Masayoshi Yamamoto, 山本真義, 山本真義, 山本真義, 山本真義, 山本真義]
通讯作者: 山本真義
DOI: 10.1158/0008-5472.can-08-1748
发表时间: 2008-12
期刊: Cancer research
影响因子: 11.2
作者: [Masayoshi Yamamoto;H. Kikuchi;M. Ohta;Toshiki Kawabata;Y. Hiramatsu;K. Kondo;Megumi Baba;K. Kamiya;Tatsuo Tanaka;M. Kitagawa;H. Konno]
通讯作者: Masayoshi Yamamoto;H. Kikuchi;M. Ohta;Toshiki Kawabata;Y. Hiramatsu;K. Kondo;Megumi Baba;K. Kamiya;Tatsuo Tanaka;M. Kitagawa;H. Konno
大腸癌肝転移におけるCXCL1/CXCR2の関与および血管新生阻害剤TSU68による肝転移制御メカニズムの解明
阐明CXCL1/CXCR2参与结直肠癌肝转移及血管生成抑制剂TSU68控制肝转移的机制
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yamamoto, Hirotoshi Kikuchi, Manabu Ohta, Toshiki Kawabata, Yoshihiro Hiramatsu, Kenji Kondo, Megumi Baba, Kinji Kamiya, Tatsuo Tanaka, Masatoshi Kitagawa, Hiroyuki Konno, 山本真義, Masayoshi Yamamoto, 山本真義, 山本真義]
通讯作者: 山本真義
Optimization of mountaineerer's physical fitness with purposing mountain route
Self check of physical fitness and training status for safe mountaineering
Construction of dose estimation model for low dose radiation exposurefor residents living around the Semipalatinsk Nuclear Test Site
  • 批准号:
    22404004
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $10.65万
  • 财政年份:
    2010
  • 负责人:
    YAMAMOTO Masayoshi
  • 依托单位:
Prevention of mountaineering accidents from the viewpoint of exercise physiology
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