Elucidation for Regulation of Chromatin Function and Reprogramming of iPS Cells by Tumor Suppressor p53 and Its Transcriptional Complex

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Recent several lines of evidence have suggested that the concept regarding “cancer stem cell" is associated with the pathogenesis of drug-resistant or cancer recurrence. However, a little is known about how Oct3/4, Sox2, Klf-4, c-Myc and tumor suppressor p53 can regulate pluripotency and reprogramming process. Here, we have focused on p53 and Yamanaka 4 factors, and attempted to elucidate the common epigenetic mechanism between cancer stem cells and iPS/ES cells by the combination of cross-linking methodology and genome-wide analysis. Trascriptome analysis revealed the identification of cancer and iPS specific non-coding RNA including long intergenic RNA (linc RNA) as well as GLS2 which are important for the maintenance of stemness. Furthermore, we found the tumor suppressor and anti-metastatic function of certain genes in vitro and in