Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies

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ABSTRACT Support is requested for a Keystone Symposia conference entitled Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies, organized by Drs. Shelia Violette, Neil Henderson, Benjamin Humphreys and Melanie Koenigshoff. The conference will be held in Keystone, Colorado from June 12-16, 2022. Fibrosis is a final common pathway in many forms of organ failure and a major cause of morbidity and mortality worldwide. Classically, fibrosis is characterized by aberrant fibroblast activation and inadequate tissue repair. While advances have been made in the understanding of molecular mechanisms driving tissue injury and fibrosis, there remains a need to identify targets/pathways that are relevant to human disease and can be leveraged to promote repair and regeneration, as well as to develop translational strategies to facilitate clinical development of novel therapies. Therefore, this conference is designed to highlight the recent advances in the understanding of cellular and molecular mechanisms driving tissue injury and fibrosis and their potential to be leveraged to promote tissue repair and regeneration. The program will explore the interface between aging, senescence, tissue injury and fibrosis. Participants will also learn how single-cell genomics has informed cellular heterogeneity, mechanisms driving tissue injury and fibrosis, and cells/pathways that can be reprogrammed to promote repair and regeneration. Other topics that will be covered include translational advances that support the understanding of fibrotic disease and facilitating drug development, such as models of human disease; prognostic markers of disease susceptibility; biomarkers of disease activity; and non- invasive technologies to diagnose, prognosticate, and monitor therapeutic intervention. The program will also emphasize recent advances toward developing novel fibrosis therapies. This renowned conference will provide an interactive forum for early and established international investigators, illuminate novel discoveries and facilitate fruitful collaboration. Moreover, it will be held jointly with another Keystone Symposia conference on Resolution of Inflammation. The opportunity for networking and scientific collaboration between these synergistic fields will occur during shared sessions and meals for attendees at both conferences.