Resolution of Inflammation

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ABSTRACT Support is requested for a Keystone Symposia conference entitled Resolution of Inflammation, organized by Drs. Carla Rothlin, Kodi Ravichandran, Ashley Seifert and Gabrielle Fredman. The conference will be held in Keystone, Colorado from June 12-16, 2022. Resolution of inflammation involves extinguishing the inflammatory response once the infectious or damaging agent has been eliminated and triggering the repair of damaged tissues to regain physiological function. This active process is essential to health and may be aberrant in a number of diseases associated with chronic or exaggerated inflammation. The role of innate immune cells, and their production of pro-resolution chemical mediators, has been recognized for some time. A more recent discovery reports the critical role of coordination between innate immune cells and stromal cells to “re-build” injured tissues and organs. This conference will bring together an interdisciplinary group of scientists studying interactions between immune and stromal cells, and neuroimmune interactions to better understand the resolution of inflammation, and subsequent repair and regeneration. The program will explore the function of myeloid cells and fibroblasts, as well as contrasting roles of neuroimmune interactions in resolution of inflammation and pathological inflammation. This conference will also examine our current understanding of diseases that impact the resolution of inflammation, with the goal of conceptualizing and developing pro-resolution therapies. Moreover, this conference will provide a forum for the exchange of ideas that will strengthen the community of scientists interested in the fundamental mechanisms of resolution of inflammation and their translation into pharmacological approaches for the treatment of diseases driven by either lack of or aberrant resolution and repair responses. Finally, this meeting will be held jointly with another Keystone Symposia conference on Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies.