Resolution of Inflammation

摘要 请求支助题为“炎症的解决办法”的Keystone研讨会，由 Carla Rothlin，Kodi Ravichandran，Ashley Seifert和Gabrielle Fredman博士。会议将在#年举行 科罗拉多州Keystone，2022年6月12日至16日。 消炎包括消除一旦感染或损伤性的炎症反应 毒剂已被消除，并触发受损组织的修复，恢复生理功能。这 积极的过程对健康是必不可少的，在许多与慢性或慢性疾病相关的疾病中可能会出现异常 夸大了炎症。先天免疫细胞的作用及其产生的促拆分化学物质 调解人，已经被认可了一段时间。一项更新的发现报告说， 先天免疫细胞和基质细胞之间的协调，以重建受损的组织和器官。这 会议将召集一个跨学科的科学家小组，研究免疫之间的相互作用 和基质细胞，以及神经免疫相互作用，以更好地了解炎症的消退，以及 随后的修复和再生。该计划将探索髓系细胞和成纤维细胞的功能，如 以及神经免疫相互作用在消解炎症和病理中的不同作用 发炎。这次会议还将考察我们目前对影响人类健康的疾病的理解。 消解炎症，目标是概念化和开发有利于消退的疗法。 此外，这次会议将提供一个交流意见的论坛，这将加强 科学家对炎症消解的基本机制感兴趣，并将其转化为 治疗因缺乏或异常解决和治疗疾病的药理学方法 修复响应。最后，本次会议将与另一场Keystone研讨会联合举行 组织纤维化和修复：机制，人类疾病和治疗。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Resolution of Inflammation, organized by Drs. Carla Rothlin, Kodi Ravichandran, Ashley Seifert and Gabrielle Fredman. The conference will be held in Keystone, Colorado from June 12-16, 2022. Resolution of inflammation involves extinguishing the inflammatory response once the infectious or damaging agent has been eliminated and triggering the repair of damaged tissues to regain physiological function. This active process is essential to health and may be aberrant in a number of diseases associated with chronic or exaggerated inflammation. The role of innate immune cells, and their production of pro-resolution chemical mediators, has been recognized for some time. A more recent discovery reports the critical role of coordination between innate immune cells and stromal cells to “re-build” injured tissues and organs. This conference will bring together an interdisciplinary group of scientists studying interactions between immune and stromal cells, and neuroimmune interactions to better understand the resolution of inflammation, and subsequent repair and regeneration. The program will explore the function of myeloid cells and fibroblasts, as well as contrasting roles of neuroimmune interactions in resolution of inflammation and pathological inflammation. This conference will also examine our current understanding of diseases that impact the resolution of inflammation, with the goal of conceptualizing and developing pro-resolution therapies. Moreover, this conference will provide a forum for the exchange of ideas that will strengthen the community of scientists interested in the fundamental mechanisms of resolution of inflammation and their translation into pharmacological approaches for the treatment of diseases driven by either lack of or aberrant resolution and repair responses. Finally, this meeting will be held jointly with another Keystone Symposia conference on Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies.