Cortactin: integrating cadherin signalling for junctional integrity

Cortactin：整合钙粘蛋白信号以实现连接完整性

• 批准号: nhmrc : 1010489
• 负责人: Prof Alpha Yap
• 金额: $ 39.6万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cortactin-integrating-cadherin-junctional-integrity/109496
• 关键词: Cortactin; integrating; cadherin; signalling; junctional

Adhesion between cells holds the human body together and affects many aspects of our health, including normal tissue and organ function. Importantly, loss of normal cell-cell adhesion contributes to many diseases, including cancer and inflammation. One key adhesion molecule, E-cadherin, is necessary for many epithelial tissues and its function is perturbed in disease. This research project addresses how E-cadherin signals into cells to control cell-to-cell interactions.

细胞之间的粘附将人体保持在一起，并影响我们健康的许多方面，包括正常组织和器官功能。重要的是，正常细胞-细胞粘附的丧失导致许多疾病，包括癌症和炎症。一个关键的粘附分子，E-钙粘蛋白，是许多上皮组织所必需的，其功能在疾病中受到干扰。该研究项目解决了E-cadherin信号如何进入细胞以控制细胞与细胞的相互作用。