Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
批准号:
nhmrc : 511156
负责人:
Prof Alpha Yap
金额:
$37.2万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
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英文摘要
Epithelia protect the body from its environment. Breakdown of the epithelial barrier in tissues such as the skin and intestine, as occurs in burns and inflammation, leads to invasion of bacteria and severe metabolic disturbances. In this project we study the cell signaling mechanisms that maintain epithelial barriers in healthy tissues that undergo turnover and remodelling. Understanding these signaling pathways provides a foundation to understand how they are perturbed in disease.
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Regulation of dynamic cell-cell adhesions by coordinated action of lipid kinases and phosphatases
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Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins
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海外基金