MECHANISM ON SHARP PEAK FORMATION OF BROMOACETYL T3 FRACTIONATION IN CCC

CCC中溴乙酰T3分馏尖峰的形成机制

• 批准号: 3858003
• 负责人: Y ITO
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3858003
• 关键词: acetates; acidity /alkalinity; bromine; chemical synthesis; triiodothyronine

N-bromoacetyl-3,3', 5-triiodo-L-thyronine (BrAcT3) was synthesized in a one step procedure and purified by countercurrent chromatography (CCC). The CCC separation produced an unusually sharp peak of BrAcT3. Further investigation indicated that bromoacetic acid present in the crude reaction mixture was responsible for sharpening the BrAcT3 peak by making a pH gradient in the effluent of CCC.

合成了n -溴乙酰-3,3'，5-三碘- l-甲状腺原氨酸（BrAcT3）