STUDIES OF PH ZONE REFINING COUNTERCURRENT CHROMATOGRAPHY
STUDIES OF PH ZONE REFINING COUNTERCURRENT CHROMATOGRAPHY
批准号:
5203506
负责人:
Y ITO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
研究了(+/-)-二硝基苯甲酰(DNB)氨基酸的手性分离
英文摘要
Chiral separation of (+/-)-dinitrobenzoyl(DNB) amino acids was
successfully performed in both analytical and preparative scales by
high-speed CCC, using a chiral selector (CS), N-dodecanoyl-L-proline-
3,5-dimethylanilide. The separations were carried out with a two-phase
solvent system composed of hexane/ethyl acetate/ methanol/10mM HCl
(8:2:5:5) by adding a proper amount of the CS in the organic stationary
phase. The sample size ranging up to 2g was separated in 2-7 hours.
Various parameters involved in the chiral resolution were investigated
using a set of DNB-amino acid racemates. The results indicated that
increasing the concentration of the CS in the stationary phase improves
both separation factor (alpha) and peak resolution (Rs). Increasing the
hydrophobicity of the solvent system also increased the alpha of the
racemate while it affected the peak resolution differently according to
the partition coefficient of the racemate. Our results indicated that
the best separation will be achieved by applying a high CS concentration
and adjusting the hydrophobicity of the solvent system so that the
partition coefficient of (K) the racemates falls between 0.6 and 0.8.
A simple mathematical analysis on the chiral separation shows good
agreement with the experimental data.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1007/s10840-011-9580-2
发表时间:
2011-11
期刊:
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
影响因子:
1.8
作者:
[Lim, Phang Boon, Malcolme-Lawes, Louisa C., Stuber, Thomas, Koa-Wing, Michael, Wright, Ian J., Tillin, Therese, Sutton, Richard, Davies, D. Wyn, Peters, Nicholas S., Francis, Darrel P., Kanagaratnam, Prapa]
通讯作者:
Kanagaratnam, Prapa
COUNTERCURRENT CHROMATOGRAPHY FOR SEPARATION OF POLAR COMPOUNDS
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批准号:4694537
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
MECHANISM ON SHARP PEAK FORMATION OF BROMOACETYL T3 FRACTIONATION IN CCC
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批准号:3858003
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
FOAM COUNTERCURRENT CHROMATOGRAPHY WITH A COIL PLANET CENTRIFUGE
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批准号:3899183
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
CROSS-AXIS SYNCHRONOUS FLOW-THROUGH COIL PLANET CENTRIFUGE
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批准号:3858015
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
PREPARATIVE HIGH-SPEED COUNTERCURRENT CHROMATOGRAPH
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批准号:3878927
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
ANALYTIC HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY WITH A COIL PLANET CENTRIFUGE
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批准号:3920044
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
STUDIES OF PH-ZONE REFINING COUNTERCURRENT CHROMATOGRAPHY
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批准号:3843286
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
STUDIES OF PH-ZONE REFINING COUNTERCURRENT CHROMATOGRAPHY
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批准号:3757624
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
HORIZONTAL FLOW-THROUGH COIL PLANET CENTRIFUGE WITH MULTILAYER COIL SET
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批准号:3899182
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
A NEW ANGIE ROTOR SYNCHRONOUS COIL PLANET CENTRIFUGE FOR CHROMATOGRAPHY
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批准号:3966585
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
SEPARATION OF MAST CELLS BY COIL PLANET CENTRIFUGE
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批准号:3779527
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
COLUMN CONFIGURATION FOR PROTEIN SEPARATION--TOROIDAL CENTRIFUGE CHROMATOGRAPHY
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批准号:2441402
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
MULTISTAGE MIXER SETTLER PLANETARY
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批准号:3920046
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
EVALUATION OF ANALYTICAL COUNTERCURRENT CHROMATOGRAPHS
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批准号:3878937
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
SEPARATION OF PROTEINS BY AQUEOUS-AQUEOUS POLYMER PHASE SYSTEMS
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批准号:3843284
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
MECHANISM OF UNILATERAL DISTRIBUTION OF TWO SOLVENT PHASES IN THE ROTATING COIL
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批准号:3966586
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
DEVELOPMENT OF FOAM COUNTERCURRENT CHROMATOGRAPHY
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批准号:4694542
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
MECHANISM OF UNILATERAL DISTRIBUTION OF TWO SOLVENT PHASES IN THE ROTATING COIL
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批准号:3942826
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
CROSS-AXIS SYNCHRONOUS FLOW-THROUGH COIL PLANET CENTRIFUGE
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批准号:3779536
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
PREPARATIVE HIGH-SPEED COUNTERCURRENT CHROMATOGRAPH WITH THREE MULTILAYER COILS
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批准号:3858002
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Y ITO
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依托单位:
海外基金