THE EFFECT OF BROMOCRIPTINE ON HUMAN UVEITIS

溴隐亭对人类葡萄膜炎的作用

• 批准号: 3898140
• 负责人: A G PALESTINE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3898140
• 关键词: autoimmune disorder; bromocriptine; combination chemotherapy; cyclosporines; dosage; drug adverse effect; eye disorder chemotherapy; human subject; human therapy evaluation; immunopharmacology; immunoregulation; immunosuppression; lymphocyte; neuroendocrine system; placebos; prolactin; uveitis

In recent years the literature has contained increasing evidence that pituitary hormones are capable of regulating the immune system. There is evidence to suggest that prolactin is an immunostimulatory hormone and that reduction of serum prolactin levels in experimental animals by hypophysectomy or treatment with bromocriptine will result in a degree of immunosuppression. This information has been applied to humans, and two clinical studies have begun. Both are in early phases of patient recruitment. One study is a randomized trial comparing placebo and bromocriptine in recurrent anterior uveitis. Using as outcome the number of recurrences per year, the study will determine whether bromocriptine is capable of regulating the immune system in these patients. The second trial focuses on the additive effects of cyclosporine plus bromocriptine in attempts to treat patients with posterior uveitis at lower doses of cyclosporine to reduce renal toxicity while achieving immunosuppression. Cyclosporine and prolactin compete for binding sites on the lymphocyte. Further studies wt be designed to elucidate other aspects of the neuroendocrine axis that may be used to regulate the immune system in the treatment of autoimmune diseases.

近年来，文献中包含了越来越多的证据， 垂体激素能够调节免疫系统。 有 有证据表明催乳素是一种免疫刺激激素， 降低实验动物的血清催乳素水平 垂体切除术或溴隐亭治疗将导致一定程度的 免疫抑制 这一信息已应用于人类，两项临床研究 开始. 两者都处于患者招募的早期阶段。 一项研究是 一项比较安慰剂和溴隐亭治疗复发性前房 色素层炎。 使用每年复发次数作为结果， 将决定溴隐亭是否能够调节免疫 这些患者的系统。 第二次试验侧重于累加效应 环孢菌素加溴隐亭， 低剂量环孢素治疗后葡萄膜炎以减少肾毒性 同时实现免疫抑制。 环孢菌素和催乳素竞争 淋巴细胞上的结合位点。 进一步研究的目的是 阐明神经内分泌轴的其他方面，可用于 调节免疫系统治疗自身免疫性疾病。