THE EFFECT OF BROMOCRIPTINE ON HUMAN UVEITIS

溴隐亭对人类葡萄膜炎的作用

• 批准号: 3941664
• 负责人: A G PALESTINE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941664
• 关键词: autoimmune disorder; bromocriptine; combination chemotherapy; cyclosporines; dosage; drug adverse effect; eye disorder chemotherapy; human subject; human therapy evaluation; immunopharmacology; immunosuppression; lymphocyte; neuroendocrine system; placebos; prolactin; uveitis

In recent years there has been increasing evidence in the literature that pituitary hormones are capable of regulating the immune system. There is evidence to suggest that prolactin is an immunostimulatory hormone and that reduction of serum prolactin levels in experimental animals by hypothesectomy or bromocriptine will result in a degree of immunosuppression. This information has been applied to humans and two clinical studies have begun. Both of these are in early phase of patient recruitment. One study is a randomized trial between placebo and bromocriptine in recurrent anterior uveitis using the end point of the number of recurrences per year to determine whether or not bromocriptine is capable of regulating the immune system in these patients. The second trial focuses on the additive effects of cyclosporine plus bromocriptine in attempts to treat patients with posterior uveitis at lower doses of cyclosporine in order to reduce its concurrent renal toxicity while at the same time achieving an immunosuppressive effect. Cyclosporine and prolactin compete for binding sites on the lymphocyte. Further studies in human disease will hopefully elucidate other aspects of the neuroendocrine axis which can be utilized to regulate the immune system to treat autoimmune diseases.

近年来，越来越多的证据表明， 文献表明垂体激素能够调节 免疫系统 有证据表明，催乳素是一种 免疫刺激激素与血清 通过假孕切除术或 溴隐亭将导致一定程度的免疫抑制。 这一信息已被应用于人类和两个临床 研究已经开始。 这两种都是早期的病人 招聘 一项研究是一项随机试验， 和溴隐亭治疗复发性前葡萄膜炎的终点 每年复发的次数，以确定是否或 溴隐亭不能调节免疫系统， 这些病人。 第二次试验侧重于以下因素的累加效应： 环孢素+溴隐亭治疗 后葡萄膜炎在较低剂量的环孢素，以减少 其并发的肾毒性，同时实现 免疫抑制作用。 环孢素和催乳素竞争 淋巴细胞上的结合位点。 对人类疾病的进一步研究将有望阐明其他 神经内分泌轴的各个方面，可用于 调节免疫系统以治疗自身免疫性疾病。