ENDOCRINE MODULATION OF IMMUNE-MEDIATED EYE DISEASE IN RATS

大鼠免疫介导眼病的内分泌调节

• 批准号: 3965391
• 负责人: A G PALESTINE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965391
• 关键词: antigens; autoimmune disorder; bromocriptine; combination chemotherapy; cyclosporines; disease /disorder model; dosage; eye disorder chemotherapy; hormone regulation /control mechanism; immunization; immunopharmacology; immunosuppression; inflammation; model design /development; neuroendocrine system; prolactin; uveitis

In recent years there has been increasing evidence in the literature that pituitary hormones are capable of regulating the immune system. There is evidence to suggest that prolactin is an immunostimulatory hormone and that reduction of serum prolactin levels in experimental animals by hypothesectomy or bromocriptine will result in a degree of immunosuppression. An animal model of experimental autoimmune uveitis (EAU) induced by immunization of rats with S-antigen (a soluble antigen from the retina) is used as a model for intraocular inflammatory disease. We have demonstrated that concurrent antibody production in both males and females and the incidence of uveitis in female animals but did not have a significant effect on the immune responses measured by lymphocyte proliferation. As reported before, cyclosporine in high doses (10 mg/kg) there is only partial effect. We have demonstrated that the concurrent use of bromocriptine to suppress prolactin in combination with low dose cyclosporine is more effective than either drug separately in suppressing both the incidence of disease as well as the cellular and humoral immune responses to immunization. There is evidence in the literature to suggest that cyclosporine is able to compete for binding on the lymphocyte by prolactin and that reductions in prolactin level may therfore make cyclosporine more effective. Further studies in animal disease will hopefully elucidate other aspects of the neuroendocrine axis which can be utilized to regulate the immune system to treat autoimmune diseases.

近年来，文献中有越来越多的证据表明， 垂体激素能够调节免疫系统。 有 有证据表明催乳素是一种免疫刺激激素， 降低实验动物的血清催乳素水平 假设切除术或溴隐亭将导致一定程度的 免疫抑制 实验性自身免疫性葡萄膜炎（EAU）动物模型的建立 用S-抗原（来自视网膜的可溶性抗原）免疫大鼠， 用作眼内炎性疾病的模型。 我们已经证明 同时在男性和女性中产生抗体， 在雌性动物中葡萄膜炎的发病率，但没有显著的 对通过淋巴细胞增殖测量的免疫应答的影响。 作为 之前报道，环孢菌素在高剂量（10 mg/kg）时， 部分效应 我们已经证明， 溴隐亭联合低剂量 环孢霉素比单独使用任何一种药物都更有效地抑制 疾病的发病率以及细胞和体液免疫 免疫反应。 文献中有证据表明 环孢霉素能够通过竞争结合淋巴细胞， 催乳素，催乳素水平的降低可能因此使 环孢素更有效。 对动物疾病的进一步研究将 希望能阐明神经内分泌轴的其他方面， 用于调节免疫系统以治疗自身免疫性疾病。