ENDOCRINE MODULATION OF IMMUNE-MEDIATED EYE DISEASE IN RATS

近年来，文献中有越来越多的证据表明 脑下垂体激素能够调节免疫系统。的确有 有证据表明催乳素是一种免疫刺激激素，而且 安慰剂对实验动物血清催乳素水平的影响 假体切除或溴隐亭将导致一定程度的 免疫抑制。 实验性自身免疫性葡萄膜炎(EAU)动物模型的建立 S抗原(视网膜可溶性抗原)免疫大鼠的研究 用作眼内炎性疾病的模型。我们已经证明了 男性和女性同时产生的抗体和 雌性动物中葡萄膜炎的发病率，但没有显著的 以淋巴细胞增殖率衡量对免疫反应的影响。AS 以往报道，环孢素在高剂量(10 mg/kg)时仅有 部分效应。我们已经演示了并发使用 溴隐亭联合小剂量抑制催乳素 环孢素单独用药比单独用药更有效 疾病的发病率以及细胞免疫和体液免疫 对免疫的反应。文献中有证据表明 环孢素能够通过以下方式竞争与淋巴细胞的结合 催乳素和催乳素水平降低可能因此导致 环孢素效果更好。对动物疾病的进一步研究将 希望阐明神经内分泌轴的其他方面，这些方面可以 用于调节免疫系统以治疗自身免疫性疾病。

In recent years there has been increasing evidence in the literature that pituitary hormones are capable of regulating the immune system. There is evidence to suggest that prolactin is an immunostimulatory hormone and that reduction of serum prolactin levels in experimental animals by hypothesectomy or bromocriptine will result in a degree of immunosuppression. An animal model of experimental autoimmune uveitis (EAU) induced by immunization of rats with S-antigen (a soluble antigen from the retina) is used as a model for intraocular inflammatory disease. We have demonstrated that concurrent antibody production in both males and females and the incidence of uveitis in female animals but did not have a significant effect on the immune responses measured by lymphocyte proliferation. As reported before, cyclosporine in high doses (10 mg/kg) there is only partial effect. We have demonstrated that the concurrent use of bromocriptine to suppress prolactin in combination with low dose cyclosporine is more effective than either drug separately in suppressing both the incidence of disease as well as the cellular and humoral immune responses to immunization. There is evidence in the literature to suggest that cyclosporine is able to compete for binding on the lymphocyte by prolactin and that reductions in prolactin level may therfore make cyclosporine more effective. Further studies in animal disease will hopefully elucidate other aspects of the neuroendocrine axis which can be utilized to regulate the immune system to treat autoimmune diseases.