ENDOCRINE MODULATION OF IMMUNE-MEDIATED EYE DISEASE IN RATS

近年来，有越来越多的证据表明， 荷尔蒙能够调节免疫的文献 系统。有证据表明，催乳素是一种 免疫刺激激素与血清催乳素降低 实验动物经下丘脑摘除或应用 溴隐亭会导致一定程度的免疫抑制。 实验性自身免疫性葡萄膜炎动物模型的建立 用S抗原(中国仓鼠的一种可溶性抗原)免疫大鼠 视网膜)用于研究眼内炎症性疾病。我们有 显示出男性和男性的抗体产生都减少了 雌性大鼠和雌性动物葡萄膜炎发病率下降 但对免疫反应没有显著影响 淋巴细胞增殖。正如之前报道的那样，高剂量的 环孢素(10 mg/kg)仅部分减少 眼内炎症。我们已经证明了 溴隐亭合用对兔催乳素的抑制作用 与小剂量环孢素联合应用效果优于 两种药物分别在抑制两者发病中的作用 以及细胞和体液免疫反应。证据中的证据 文献表明，环孢素与催乳素竞争 淋巴细胞上的结合部位因此减少了催乳素 水平可能会减少对这些位置的竞争，并使环孢素 治疗更有效。对该动物模型的进一步研究 将阐明神经内分泌轴的其他方面，可能 用于调节免疫系统治疗自身免疫 疾病。

In recent years there has been increasing evidence in the literature that hormones are capable of regulating the immune system. There is evidence to suggest that prolactin is an immunostimulatory hormone and that reduction of serum prolactin levels in experimental animals by hypothesectomy or treatment with bromocriptine will result in a degree of immunosuppression. An animal model of experimental autoimmune uveitis (EAU) induced by immunization of rats with S-antigen (a soluble antigen from the retina) is used to study intraocular inflammatory disease. We have demonstrated a decrease in antibody production in both male and female rats and a decreased incidence of uveitis in female animals but no significant effect on the immune responses measured by lymphocyte proliferation. As reported before, high doses of cyclosporine (10 mg/kg) results in only partial reduction of intraocular inflammation. We have demonstrated that the suppression of prolactin by concurrent use of bromocriptine in combination with low dose cyclosporine is more effective than either drug separately in suppressing both the incidence of disease as well as cellular and humoral immune responses. Evidence in the literature suggests that cyclosporine competes with prolactin for binding sites on lymphocytes therefore reductions in prolactin level may reduce competition for those sites and make cyclosporine treatment more effective. Further studies with this animal model will elucidate other aspects of the neuroendocrine axis that may be utilized to regulate the immune system to treat autoimmune diseases.