THE EFFECT OF BROMOCRIPTINE ON HUMAN UVEITIS

近年来，文献中有越来越多的证据表明， 垂体激素能够调节免疫系统。 有 有证据表明催乳素是一种免疫刺激激素， 降低实验动物的血清催乳素水平 假设切除术或溴隐亭将导致一定程度的 免疫抑制 这一信息已应用于人类，两项临床研究 开始. 这两种情况都处于患者招募的早期阶段。 一项研究 是一项安慰剂和溴隐亭在复发性 前葡萄膜炎以每年复发次数为终点 以确定溴隐亭是否能够调节 这些患者的免疫系统。 第二次试验重点关注添加剂 环孢霉素联合溴隐亭治疗急性白血病的疗效 在较低剂量的环孢霉素，以减少后葡萄膜炎， 其并发的肾毒性，同时实现 免疫抑制作用。 环孢菌素和催乳素竞争结合 淋巴细胞上的位点。 对人类疾病的进一步研究将有望阐明 可用于调节免疫系统的神经内分泌轴 来治疗自身免疫性疾病

In recent years there has been increasing evidence in the literature that pituitary hormones are capable of regulating the immune system. There is evidence to suggest that prolactin is an immunostimulatory hormone and that reduction of serum prolactin levels in experimental animals by hypothesectomy or bromocriptine will result in a degree of immunosuppression. This information has been applied to humans and two clinical studies have begun. Both of these are in early phase of patient recruitemnt. One study is a randomized trial between placebo and bromocriptine in recurrent anterior uveitis using the end point of the number of recurrences per year to determine whether or not bromocriptine is capable of regulating the immune system in these patients. The second trial focuses on the additive effects of cyclosporine plus bromocriptine in attempts to treat patients with posterior uveitis at lower doses of cyclosporine in order to reduce its concurrent renal toxicity while at the same time achieving an immunosuppressive effect. Cyclosporine and prolactin compete for binding sites on the lymphocyte. Further studies in human disease will hopefully elucidate other aspects of the neuroendocrine axis which can be utilized to regulate the immune system to treat autoimmune diseases.