THE EFFECT OF BROMOCRIPTINE ON HUMAN UVEITIS

溴隐亭对人类葡萄膜炎的作用

• 批准号: 3965390
• 负责人: A G PALESTINE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965390
• 关键词: autoimmune disorder; bromocriptine; combination chemotherapy; cyclosporines; dosage; drug adverse effect; eye disorder chemotherapy; hormone metabolism; human subject; human therapy evaluation; immunopharmacology; immunosuppression; lymphocyte; neuroendocrine system; prolactin; uveitis

In recent years there has been increasing evidence in the literature that pituitary hormones are capable of regulating the immune system. There is evidence to suggest that prolactin is an immunostimulatory hormone and that reduction of serum prolactin levels in experimental animals by hypothesectomy or bromocriptine will result in a degree of immunosuppression. This information has been applied to humans and two clinical studies have begun. Both of these are in early phase of patient recruitemnt. One study is a randomized trial between placebo and bromocriptine in recurrent anterior uveitis using the end point of the number of recurrences per year to determine whether or not bromocriptine is capable of regulating the immune system in these patients. The second trial focuses on the additive effects of cyclosporine plus bromocriptine in attempts to treat patients with posterior uveitis at lower doses of cyclosporine in order to reduce its concurrent renal toxicity while at the same time achieving an immunosuppressive effect. Cyclosporine and prolactin compete for binding sites on the lymphocyte. Further studies in human disease will hopefully elucidate other aspects of the neuroendocrine axis which can be utilized to regulate the immune system to treat autoimmune diseases.

近年来，文献中有越来越多的证据表明 脑下垂体激素能够调节免疫系统。的确有 有证据表明催乳素是一种免疫刺激激素，而且 安慰剂对实验动物血清催乳素水平的影响 假体切除或溴隐亭将导致一定程度的 免疫抑制。 这一信息已经应用于人类，两项临床研究已经 开始了。这两个都处于患者招募的早期阶段。一项研究 是一项在安慰剂和溴隐亭之间治疗复发的随机试验 以前葡萄膜炎为终点的每年复发次数 以确定溴隐亭是否能够调节 这些患者的免疫系统。第二次试验的重点是添加剂 环孢素联合溴隐亭治疗患者的疗效观察 用小剂量环孢素治疗后葡萄膜炎以减少 其同时存在的肾脏毒性，同时实现了 免疫抑制作用。环孢素与催乳素竞争结合 淋巴细胞上的位置。 对人类疾病的进一步研究有望阐明疾病的其他方面 可用于调节免疫系统的神经内分泌轴 治疗自身免疫性疾病。