CREATION OF MOUSE GENE DISRUPTION FOR LYSOSOMAL ALPHA MANNOSIDASE

溶酶体α甘露糖苷酶小鼠基因破坏的产生

• 批准号: 6122189
• 负责人: KELLEY W. MOREMEN
• 金额: $ 0.11万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122189
• 关键词: Mammalia; biomedical resource; carbohydrates; enzymes; gene therapy; genetically modified animals; genetics; nervous system; technology /technique

We are collaborating on the generation of a mouse gene knockout for the lysosomal ?-mannosidase as an animal model for the human genetic disease ?-mannosidosis. Gene disruption constructs prepared in the Moremen laboratory are being used by Dr. Condie to generate the knockout mice. The homozygous null mice will be analyzed in the Moremen laboratory for the storage phenotype and potentially used as a model for the testing of therapeutic strategies.

我们正在合作制造一种基因敲除小鼠 对于溶酶体？甘露糖苷酶作为人类的动物模型 遗传病？甘露糖苷中毒 制备的基因破坏构建体 被康迪博士用来产生 敲除小鼠 纯合无效小鼠将在 Moremen实验室的储存表型，并可能用作 用于测试治疗策略的模型。