Tumor Suppressors and Stem Cell Biology

肿瘤抑制剂和干细胞生物学

• 批准号: 7407606
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-15 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7407606
• 关键词: Aging; Biological; British Columbia; Canada; Cancer Biology; Cellular biology; Complex; Development; Equilibrium; Homeostasis; Link; Maintenance; Malignant Neoplasms; Natural regeneration; Organism; Physiological; Play; Regulation; Reproduction; Role; Stem cells; Tissues; Tumor Suppressor Proteins; cancer cell; self-renewal; symposium; tumorigenesis

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled "Tumor Suppressors and Stem Cell Biology", organized by Sean J. Morrison and Alejandro S nchez Alvarado, which will be held in British Columbia, Canada from February 24 - 29, 2008. Stem cells play key roles in the development, maintenance, and reproduction of all known multicellular organisms. Stem cells operate in a wide variety of biological contexts from homeostasis to regeneration and must be subject to complex and robust regulation. Recent evidence suggests that tumor suppressor mechanisms, originally discovered for their ability to inhibit tumorigenesis, also play widespread roles in the physiological regulation of stem cells. Tumor suppressors play critical roles in the regulation of tissue homeostasis, stem cell self-renewal, regeneration, and aging. This reveals mechanistic links between the regulation of stem cells, and the regulation of cancer cells that could potentially be exploited to target cancer and to enhance regeneration. The dual roles of these mechanisms in stem cell and cancer biology illuminate the evolved balance between the promotion of regeneration and the suppression of cancer.

描述（由申请人提供）：本提案旨在请求支持由Sean J.莫里森和Alejandro S nchez阿尔瓦拉多组织的题为“肿瘤抑制剂和干细胞生物学”的Keystone研讨会会议，该会议将于2008年2月24日至29日在加拿大不列颠哥伦比亚省举行。 干细胞在所有已知的多细胞生物的发育、维持和繁殖中起着关键作用。 干细胞在从稳态到再生的各种生物学背景下运作，并且必须受到复杂和强大的调控。 最近的证据表明，肿瘤抑制机制，最初发现的能力，抑制肿瘤发生，也发挥了广泛的作用，在生理调节干细胞。 肿瘤抑制因子在组织稳态、干细胞自我更新、再生和衰老的调节中起关键作用。 这揭示了干细胞调节和癌细胞调节之间的机制联系，这些机制可能被用于靶向癌症和增强再生。 这些机制在干细胞和癌症生物学中的双重作用阐明了促进再生和抑制癌症之间的进化平衡。