RNAi, MicroRNA, and Non-Coding RNA

描述(由申请人提供)：本提案旨在请求支持由Judy Lieberman和Phillip A.Sharp组织的题为“RNAi、microRNA和非编码RNA”的Keystone研讨会，该会议将于2008年3月25-30日在加拿大不列颠哥伦比亚省举行。RNA干扰(RNAi)描述了多种进化上保守的机制来调节基因转录和转录后事件，这些事件对于控制发育和细胞增殖、存活、分化和效应功能是重要的。RNAi还可以保护基因组免受转座子和病毒的侵袭。本次会议将探讨在理解基于RNA的转录后沉默的分子机制和细胞生物学以及保持染色质沉默区域方面的最新进展。它将考虑揭示内源性microRNA及其目标基因的调控网络的方法，以及在各种生物体中的说明性例子。还将探讨利用RNA干扰进行遗传筛选和治疗性基因沉默的最新进展。

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled "RNAi, MicroRNA, and Non-Coding RNA", organized by Judy Lieberman and Phillip A. Sharp, which will be held in British Columbia, Canada from March 25 - 30, 2008. RNA interference (RNAi) describes a variety of evolutionarily conserved mechanisms for regulating gene transcription and post-transcriptional events that are important for controlling development and cell proliferation, survival, differentiation and effector functions. RNAi also protects the genome from transposons and viruses. This meeting will explore recent developments in understanding the molecular mechanisms and cell biology of RNA-based post-transcriptional silencing and for maintaining regions of silenced chromatin. It will consider methods to uncover regulatory networks of endogenous microRNAs and their target genes and illustrative examples in a variety of organisms. Recent advances in harnessing RNA interference for genetic screening and therapeutic gene silencing will also be explored.