Atherosclerosis Risk in Communities - Retinal component

我们调查了981名中年ARIC研究参与者的视网膜病变的发病率和患病率，这些参与者被选中参加第三次和第四次ARIC研究检查，并在两次研究访问中拍摄了同一只眼睛的视网膜照片。视网膜病变的患病率为7.7%，其中3.8%的人在检查间隔的三年内出现视网膜病变的迹象。虽然糖尿病患者的视网膜病变发生率较高（147例中有40例），但非糖尿病患者的视网膜病变发生率也相当（834例中有36例）。增加视网膜病变风险的因素包括较高的血压、空腹血糖、总胆固醇和血浆纤维蛋白原。

We investigated the incidence and prevalence of retinopathy in a sample of 981 middle-aged ARIC study participants who were selected to participate in the third and fourth ARIC study examinations and who had retinal photographs of the same eye taken at both study visits. The prevalence of retinopathy was 7.7%, with 3.8% of people developing signs of retinopathy in the three year interval between exams. Although the rate of retinopathy was found to be higher among diabetics (40 of 147), a comparable number of cases occurred in non-diabetic individuals (36 of 834). Factors found to increase risk of retinopathy include higher levels of blood pressure, fasting serum glucose, total cholesterol, and plasma fibrinogen. For more information about the study, including the full list of investigators and participating institutions and resulting publications, see http://www.cscc.unc.edu/carmri/ Data analysis of phenotype and genotype data is on-going. Findings from this study are being merged with those from other aging and cardiovascular cohorts to allow for increased power to detect genetic signals of disease.