Multi-ethnic Study Of Atherosclerosis - Vision Component

动脉粥样硬化的多种族研究 - 视觉成分

• 批准号: 10260288
• 负责人: Mary Frances Cotch
• 金额: $ 22.81万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260288
• 关键词: African American; Aging; Air Pollution; American; Ancillary Study; Asian Americans; Atherosclerosis; Biological; Candidate Disease Gene; Cardiovascular Diseases; Cardiovascular system; Clinical; Cohort Studies; Collaborations; Communities; Contracts; DNA; Data; Data Analyses; Deposition; Diabetic Retinopathy; Disease; Enrollment; Ethnic Origin; Event; Eye; Family; Family Study; Family member; Funding; Funding Agency; Fundus photography; Genes; Genetic; Genome Scan; Genotype; Grant; Health; Hispanic Americans; Individual; Institution; Interdisciplinary Study; International; Intramural Research Program; Laboratories; Longitudinal Studies; Lung; Macular degeneration; Manuscripts; Measures; Meta-Analysis; Methodology; Microvascular Dysfunction; Monitor; Multi-Ethnic Study of Atherosclerosis; National Heart, Lung, and Blood Institute; Parents; Participant; Pathology; Peer Review; Phenotype; Photography; Policies; Predictive Factor; Preparation; Principal Investigator; Procedures; Protocols documentation; Publications; Publishing; Reading; Research; Research Personnel; Resources; Retina; Role; Sampling; Schedule; Severities; Siblings; Systemic disease; Testing; Time; Ultrasonography; Variant; Vision; Visit; Visual; Visual Acuity; Visual impairment; Woman; Work; X-Ray Computed Tomography; aged; caucasian American; clinical phenotype; cohort; database of Genotypes and Phenotypes; design; digital; genetic analysis; genetic association; genetic linkage analysis; genome-wide; genomic epidemiology; high risk; imaging modality; indexing; innovation; international partnership; member; men; novel; phenotypic data; population based; retinal imaging; sex; trait

The longitudinal MESA study, is on-going and in its 20th year. MESA study visit five, which collected eye data, began in April 2010 and was completed in early 2012. MESA study visit exam six took place between September 2016 and June 2019 and although it did not collect eye data, participants were followed for health events. Planning is underway for a seventh exam scheduled for October 2020. Analyses of various ocular phenotypes, including retinal microvascular disease, have resulted in over 50 published manuscripts with more under preparation. Genotype and ocular phenotype data began to be released on dbGaP in August 2010. Genetic analyses under the auspices of MESA SHARe, CHARGE, and the BioProject have resulted in several publications. MESA has numerous ancillary studies, including a lung component (funded by NHLBI) and an air pollution component (funded by the EPA), allowing all investigators to make innovative use of a visionary and generously funded NHLBI research cohort platform and leverage modest resources from other funding sources for maximal scientific advantage. Discussions to integrate and analyze data across various study components have resulted in several multi-disciplinary collaborations producing numerous peer-reviewed scientific publications, many of which are novel and would likely have been considered too high-risk or expensive to have ever received funding on their own. MESA, with its highly collaborative team approach, has been actively involved in numerous international collaborations and consortia. Work on manuscripts analyzing data from this longitudinal study continues actively in 2020. More information about the MESA Study and its ancillary studies, including a full list of participating investigators and institutions, study Committees, policies and procedures, and a complete, up-to-date list of over 2000 publications, can be found at http://www.mesa-nhlbi.org. For information on how to access MESA data, refer to dbGaP (http://www.ncbi.nlm.nih.gov/gap).

梅萨纵向研究正在进行中，已进入第20个年头。 梅萨第五次研究访问收集了眼部数据，于2010年4月开始，并于2012年初完成。 梅萨第六次研究访问检查于2016年9月至2019年6月期间进行，尽管没有收集眼睛数据，但对参与者进行了健康事件随访。 计划于2020年10月举行第七次考试。 对包括视网膜微血管疾病在内的各种眼部表型的分析已经导致了50多篇已发表的手稿，还有更多的手稿正在准备中。2010年8月，基因型和眼部表型数据开始在dbGaP上发布。 在梅萨SHARe、CHARGE和BioProject的主持下进行的遗传分析已发表了几篇论文。 梅萨有许多辅助研究，包括肺部部分（由NHLBI资助）和空气污染部分（由EPA资助），允许所有研究人员创新地利用有远见和慷慨资助的NHLBI研究队列平台，并利用其他资金来源的适度资源以获得最大的科学优势。 整合和分析各种研究组成部分的数据的讨论导致了几个多学科合作，产生了许多同行评审的科学出版物，其中许多是新颖的，可能被认为风险太高或太昂贵，无法单独获得资助。 梅萨以其高度协作的团队方法，积极参与了许多国际合作和财团。分析这项纵向研究数据的手稿工作将于2020年继续积极进行。 有关梅萨研究及其辅助研究的更多信息，包括参与研究者和机构、研究委员会、政策和程序的完整列表，以及2000多篇出版物的完整最新列表，请访问http://www.mesa-nhlbi.org。有关如何访问梅萨数据的信息，请参阅dbGaP（http：//www.ncbi.nlm.nih.gov/gap）。

项目成果

Age-related macular degeneration and progression of coronary artery calcium: The Multi-Ethnic Study of Atherosclerosis.

• DOI: 10.1371/journal.pone.0201000
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Fernandez AB;Ballard KD;Wong TY;Guo M;McClelland RL;Burke G;Cotch MF;Klein B;Allison M;Klein R
• 通讯作者: Klein R

The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia.

• DOI: 10.1016/j.ophtha.2009.07.017
• 发表时间: 2010-02
• 期刊: Ophthalmology
• 影响因子: 13.7
• 作者: Rogers S;McIntosh RL;Cheung N;Lim L;Wang JJ;Mitchell P;Kowalski JW;Nguyen H;Wong TY;International Eye Disease Consortium
• 通讯作者: International Eye Disease Consortium

Association of Diabetic Macular Edema and Proliferative Diabetic Retinopathy With Cardiovascular Disease: A Systematic Review and Meta-analysis.

• DOI: 10.1001/jamaophthalmol.2017.0988
• 发表时间: 2017-06-01
• 期刊: JAMA ophthalmology
• 影响因子: 8.1
• 作者: Xie J;Ikram MK;Cotch MF;Klein B;Varma R;Shaw JE;Klein R;Mitchell P;Lamoureux EL;Wong TY
• 通讯作者: Wong TY