Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

在AGES队列中，我们正在评估眼病的患病率和风险因素，并研究在其他器官系统（包括大脑）中表现出疾病临床体征的人的可能功能相关性。 2008年至2011年期间，对该队列中的一部分存活老年人进行了详细的随访检查;数据将在2012年秋季进行分析。 AGES是基因组流行病学心脏和衰老研究队列（CHARGE）联盟的成员。因此，它参与遗传荟萃分析，用于发现或复制疾病的遗传变异。 2009年，使用Illumina 370 CNV BeadChip阵列对AGES参与者的一个亚组进行了基因分型。外显子组芯片基因分型将于2012年秋季上市。 有关AGES研究的更多信息，请参见http://www.hjarta.is/english/ages。参考研究网站上的项目参考书目，了解已发表的论文和已出版的论文。 另见年度报告ZIAAG 007380和ZIAG 006000（Dr. Harris）。

In the AGES cohort we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. A detailed follow-up examination on a subset of surviving elderly individuals in this cohort occurred between 2008 and 2011; data to be ready for analysis in Fall 2012. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. DNA on a subgroup of the AGES participants was genotyped in 2009 using an Illumina 370CNV BeadChip array. Exome chip genotyping will become available in Fall 2012. For more information on the AGES study, see http://www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers and papers in press. See also annual reports ZIAAG007380 and ZIAG006000(Dr. Harris).