冰岛的年龄、基因/环境易感性研究 - 眼部成分-猫眼课题宝

冰岛的年龄、基因/环境易感性研究 - 眼部成分

批准号：

8556825

负责人：

Mary Frances Cotch

金额：

$32.87万

依托单位：

NATIONAL EYE INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/8556825

关键词：

Affect Age Age related macular degeneration Aging Annual Reports Atherosclerosis Bibliography Blood Vessels Body Composition Brain Candidate Disease Gene Cardiovascular system Clinic Clinic Visits Clinical Cognitive Cohort Studies Consult Contracts Cross-Sectional Studies DNA Data Degenerative polyarthritis Dementia Deposition Diabetes Mellitus Diabetic Retinopathy Disease Elderly Enrollment Environment Epidemiology Exhibits Eye Eye diseases Funding Fundus Genes Genetic Genomics Genotype Health Heart Hip region structure Home environment Hyperglycemia Iceland Individual Institutes Joints Lipids MEDLINE Measures Medical Mental Depression Meta-Analysis Metabolic Diseases Musculoskeletal Diseases National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke National Institute on Deafness and Other Communication Disorders Neurocognitive Obesity Paper Participant Pathology Pattern Persons Phenotype Planet Mars Predisposition Prevalence PubMed Publishing Pupil Relative (related person)Research Retina Retinal Risk Risk Factors Running Schedule Serum Specimen Subgroup Target Populations Testing United States National Institutes of Health Ventricular Vertebral column Visit aging gene body system cohort digital imaging exome falls follow-up genetic profiling genetic variant indexing interest lifestyle factors macula member multidisciplinary normal aging phenomics sarcopenia web site

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中文摘要

翻译

在AGES队列中，我们正在估计眼病的患病率和危险因素，并调查在其他器官系统（包括大脑）表现出疾病临床症状的患者中可能存在的功能相关性。

英文摘要

In the AGES cohort we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. A detailed follow-up examination on a subset of surviving elderly individuals in this cohort occurred between 2008 and 2011; data to be ready for analysis in Fall 2012. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. DNA on a subgroup of the AGES participants was genotyped in 2009 using an Illumina 370CNV BeadChip array. Exome chip genotyping will become available in Fall 2012. For more information on the AGES study, see http://www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers and papers in press. See also annual reports ZIAAG007380 and ZIAG006000(Dr. Harris).

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