Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

冰岛的年龄、基因/环境易感性研究 - 眼部成分

• 批准号: 8339767
• 负责人: Mary Frances Cotch
• 金额: $ 14.09万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8339767
• 关键词: Affect; Age; Age related macular degeneration; Aging; Annual Reports; Atherosclerosis; Bibliography; Blood Vessels; Body Composition; Brain; Candidate Disease Gene; Cardiovascular system; Clinic; Clinic Visits; Clinical; Cognitive; Cohort Studies; Consult; Contracts; Cross-Sectional Studies; Degenerative polyarthritis; Dementia; Deposition; Diabetes Mellitus; Diabetic Retinopathy; Disease; Elderly; Enrollment; Environment; Epidemiology; Exhibits; Eye; Eye diseases; Funding; Fundus; Genes; Genetic; Genomics; Genotype; Health; Heart; Hip region structure; Home environment; Hyperglycemia; Iceland; Individual; Institutes; Joints; Lipids; Measures; Medical; Mental Depression; Meta-Analysis; Metabolic Diseases; Musculoskeletal Diseases; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; Neurocognitive; Obesity; Paper; Participant; Pathology; Pattern; Persons; Phenotype; Predisposition; Prevalence; Publishing; Pupil; Relative (related person); Research; Retina; Retinal; Risk; Risk Factors; Running; Schedule; Serum; Specimen; Subgroup; Target Populations; Testing; United States National Institutes of Health; Ventricular; Vertebral column; Visit; aging gene; body system; cohort; digital imaging; follow-up; genetic profiling; genetic variant; interest; lifestyle factors; macula; member; normal aging; sarcopenia; web site

In the AGES cohort we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs in other organ systems. A follow-up examination on a subset of 4,000 elderly individuals in this cohort was initiated at the end of 2007 with the examination to run through September 2011. A subgroup of the AGES participants was genotyped in 2009. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. For more information on the study, see http://www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers and papers in press. See also annual reports AG007380 and AG006000(Dr. Harris).

在AGES队列中，我们正在估计眼病的患病率和危险因素，并调查在其他器官系统中表现出临床症状的人可能的功能相关性。