Multi-ethnic Study Of Atherosclerosis - Vision Component

动脉粥样硬化的多种族研究 - 视觉成分

• 批准号: 10019991
• 负责人: Mary Frances Cotch
• 金额: $ 16.52万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10019991
• 关键词: African American; Aging; Air Pollution; American; Ancillary Study; Asian Americans; Atherosclerosis; Biological; Candidate Disease Gene; Cardiovascular Diseases; Cardiovascular system; Clinical; Cohort Studies; Collaborations; Communities; Contracts; DNA; Data; Data Analyses; Deposition; Diabetic Retinopathy; Disease; Enrollment; Ethnic Origin; Event; Eye; Family; Family Study; Family member; Funding; Funding Agency; Fundus photography; Genes; Genetic; Genome Scan; Genotype; Grant; Health; Hispanic Americans; Individual; Institution; Interdisciplinary Study; International; Intramural Research Program; Laboratories; Longitudinal Studies; Lung; Macular degeneration; Manuscripts; Measures; Meta-Analysis; Methodology; Microvascular Dysfunction; Monitor; Multi-Ethnic Study of Atherosclerosis; National Heart, Lung, and Blood Institute; Parents; Participant; Pathology; Peer Review; Phenotype; Photography; Policies; Predictive Factor; Preparation; Principal Investigator; Procedures; Protocols documentation; Publications; Publishing; Reading; Research; Research Personnel; Resources; Retinal; Role; Sampling; Severities; Siblings; Systemic disease; Testing; Time; Ultrasonography; Variant; Vision; Visit; Visual; Visual Acuity; Visual impairment; Woman; Work; X-Ray Computed Tomography; aged; caucasian American; clinical phenotype; cohort; database of Genotypes and Phenotypes; design; digital; genetic analysis; genetic association; genetic linkage analysis; genome-wide; genomic epidemiology; high risk; imaging modality; indexing; innovation; international partnership; member; men; novel; phenotypic data; population based; retinal imaging; sex; trait

The longitudinal MESA study, is on-going and in its 19th year. MESA study visit five, which collected eye data, began in April 2010 and was completed in early 2012. MESA study visit exam six took place between September 2016 and June 2019 and although it did not collect eye data, participants were followed for health events. Planning is underway for a seventh exam. Analyses of various ocular phenotypes, including retinal microvascular disease, have resulted in over 50 published manuscripts with more under preparation. Genotype and ocular phenotype data began to be released on dbGaP in August 2010. Genetic analyses under the auspices of MESA SHARe, CHARGE, and the BioProject have resulted in several publications. MESA has numerous ancillary studies, including a lung component (funded by NHLBI) and an air pollution component (funded by the EPA), allowing all investigators to make innovative use of a visionary and generously funded NHLBI research cohort platform and leverage modest resources from other funding sources for maximal scientific advantage. Discussions to integrate and analyze data across various study components have resulted in several multi-disciplinary collaborations producing numerous peer-reviewed scientific publications, many of which are novel and would likely have been considered too high-risk or expensive to have ever received funding on their own. MESA, with its highly collaborative team approach, has been actively involved in numerous international collaborations and consortia. Work on manuscripts analyzing data from this longitudinal study continues actively in 2019. More information about the MESA Study and its ancillary studies, including a full list of participating investigators and institutions, study Committees, policies and procedures, and a complete, up-to-date list of over 2000 publications, can be found at http://www.mesa-nhlbi.org. For information on how to access MESA data, refer to dbGaP (http://www.ncbi.nlm.nih.gov/gap).

台地纵向研究正在进行中，已进入第19个年头。 MESA研究访问5号收集了眼睛数据，于2010年4月开始，于2012年初完成。MESA学习访问考试6在2016年9月至2019年6月期间进行，尽管没有收集眼睛数据，但参与者被跟踪了解健康事件。第七次考试的计划正在进行中。 对各种眼部表型的分析，包括视网膜微血管疾病，已经导致了50多篇已发表的手稿，还有更多的正在准备中。2010年8月，基因和眼部表型数据开始在DBGaP上发布。在Mesa Share、Charge和The BioProject的赞助下进行的遗传分析已经出版了几份出版物。 MESA有许多辅助研究，包括肺部分(由NHLBI资助)和空气污染部分(由EPA资助)，使所有研究人员能够创新地利用一个有远见和慷慨资助的NHLBI研究队列平台，并利用来自其他资金来源的少量资源，以最大限度地发挥科学优势。为整合和分析不同研究组成部分的数据而进行的讨论导致了几个多学科的合作，产生了许多同行评审的科学出版物，其中许多都是新奇的，很可能被认为风险太高或成本太高，根本无法单独获得资金。 MESA以其高度协作的团队方式，积极参与了许多国际合作和财团。分析这项纵向研究数据的手稿工作在2019年继续积极进行。 有关MESA研究及其辅助研究的更多信息，包括参与研究人员和机构、研究委员会、政策和程序的完整名单，以及2000多种出版物的完整、最新名单，可在http://www.mesa-nhlbi.org.上找到有关如何访问MESA数据的信息，请参阅DBGaP(http://www.ncbi.nlm.nih.gov/gap).