Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

2007年，调查小组发表了一篇论文，以同行评议的形式分享了作为研究概念框架基础的集体想法（见参考书目）。 本文详细介绍了AGES研究的基本原理、设计、中年队列中以前的调查结果以及未来的分析计划。 在AGES队列中，我们在485（11.5%）人中发现了脑微出血的证据; 192人有多次微出血。有视网膜微血管病变迹象的人比没有视网膜微血管病变的人更容易有多个脑微出血。 视网膜微血管异常和脑微出血可能同时发生在老年人中，特别是糖尿病患者。 2007年底开始对该队列中的4 000名老年人进行随访检查。 有关该研究的更多信息，请访问http://www.hjarta.is/english/ages 还参见Z 01 AG 007380（Harris博士）。

In 2007 the investigative team published a paper to share, in a peer-review format, the collective idease underlying the conceptual framework for the study (see bibliography). This paper presents, in great detail, the rationale for the AGES study, its design, select findings from previous investigations in the cohort during mid-life, and future analytic plans. In the AGES cohort we found evidence of brain microbleeds was found in 485 (11.5%) people; 192 people had multiple microbleeds. People with signs of retinal microvascular lesions were significantly more likely to have multiple cerbral microbleeds than were people without retinal microvascular lesions. Retinal microvascular abnormalities and microbleeds in the brain microbleeds may occur together in older adults, particularly in people with diabetes. A follow-up examination on a subset of 4,000 elderly individuals in this cohort was initiated at the end of 2007. For more information on the study, see http://www.hjarta.is/english/ages See also Z01 AG007380 (Dr. Harris).