Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

在AGES队列中，我们能够评估健康、疾病和身体功能的各种概况。关于眼睛，我们正在估计眼病的患病率和危险因素，并调查在包括大脑在内的其他器官系统中表现出疾病临床症状的人可能的功能相关性。例如，AGES数据证实，在没有糖尿病的老年人中也发现了视网膜病变；非糖尿病患者的病变占视网膜病变病例的大多数（78%）。通常视网膜病变是轻微的。肾功能障碍也可能出现在受影响的个体。

In the AGES cohort we are able to assess various profiles of health, disease, and physical function. With respect to the eyes, we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. For example, AGES data confirms that retinopathy lesions are found in older people who do not have diabetes; lesions in persons without diabetes constitute the majority (78%) of retinopathy cases. Usually the retinal lesions are mild. Kidney dysfunction is also likely to be present in affected individuals. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. AGES has partnered with international collaborators and published papers on the genetic basis of retinal vessel caliber, retinopathy, and age-related macular degeneration. For more information on the AGES study (design, progress and findings), see http://www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers. See also ZIAAG007380 and ZIAG006000(Dr. Harris).