Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

在年龄队列中，我们能够评估健康、疾病和身体功能的各种概况。在眼睛方面，我们正在估计眼部疾病的患病率和风险因素，并调查表现出其他器官系统(包括大脑)疾病的临床症状的人可能的功能相关性。例如，AGEs数据证实，在没有糖尿病的老年人中发现了视网膜病变；没有糖尿病的人的病变占视网膜病变病例的大多数(78%)。通常情况下，视网膜损伤是轻微的。肾功能障碍也可能出现在受影响的个人中。 AGES是基因组流行病学心脏和衰老研究队列(CHARE)联盟的成员。因此，它参与了发现或复制疾病遗传变异的遗传荟萃分析。AGEs与国际合作者合作，发表了关于视网膜血管口径、视网膜病变和年龄相关性黄斑变性的遗传基础的论文。 有关AGEs研究(设计、进展和发现)的更多信息，请访问http://www.hjarta.is/english/ages.有关已发表的论文，请参阅研究网站上的项目参考书目。 另见ZIAAG007380和ZIAG006000(Harris博士)。

In the AGES cohort we are able to assess various profiles of health, disease, and physical function. With respect to the eyes, we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. For example, AGES data confirms that retinopathy lesions are found in older people who do not have diabetes; lesions in persons without diabetes constitute the majority (78%) of retinopathy cases. Usually the retinal lesions are mild. Kidney dysfunction is also likely to be present in affected individuals. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. AGES has partnered with international collaborators and published papers on the genetic basis of retinal vessel caliber, retinopathy, and age-related macular degeneration. For more information on the AGES study (design, progress and findings), see http://www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers. See also ZIAAG007380 and ZIAG006000(Dr. Harris).