Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

冰岛的年龄、基因/环境易感性研究 - 眼部成分

• 批准号: 8938310
• 负责人: Mary Frances Cotch
• 金额: $ 35.64万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8938310
• 关键词: Adult Children; Affect; Age; Age related macular degeneration; Aging; Ancillary Study; Atherosclerosis; Bibliography; Blood Vessels; Body Composition; Brain; Caliber; Candidate Disease Gene; Cardiovascular system; Clinic; Clinic Visits; Clinical; Cognitive; Cohort Studies; Consult; Contracts; Cross-Sectional Studies; DNA; Data; Degenerative polyarthritis; Dementia; Deposition; Diabetes Mellitus; Diabetic Retinopathy; Disease; Elderly; Enrollment; Environment; Epidemiology; Event; Exhibits; Eye; Eye diseases; Functional disorder; Funding; Fundus; Genes; Genetic; Genomics; Genotype; Health; Heart; Hip region structure; Home environment; Hyperglycemia; Iceland; Individual; Institutes; International; Joints; Kidney; Lesion; Lipids; MEDLINE; Measures; Medical; Mental Depression; Meta-Analysis; Metabolic Diseases; Musculoskeletal Diseases; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; Neurocognitive; Obesity; Paper; Participant; Pathology; Pattern; Persons; Phenotype; Physical Function; Planet Mars; Predisposition; Prevalence; PubMed; Publishing; Pupil; Relative (related person); Research; Research Design; Retina; Retinal; Retinal Diseases; Risk; Risk Factors; Running; Schedule; Serum; Specimen; Subgroup; Survivors; Target Populations; Testing; United States National Institutes of Health; Ventricular; Vertebral column; Visit; aging gene; base; body system; cohort; digital imaging; exome; follow-up; genetic profiling; genetic variant; indexing; interest; lifestyle factors; macula; member; multidisciplinary; normal aging; phenomics; retina blood vessel structure; sarcopenia; web site

In the AGES cohort we are able to assess various profiles of health, disease, and physical function. With respect to the eyes, we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. For example, AGES data confirms that retinopathy lesions are found in older people who do not have diabetes; lesions in persons without diabetes constitute the majority (78%) of retinopathy cases. Usually the retinal lesions are mild. Kidney dysfunction is also likely to be present in affected individuals. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. AGES has partnered with international collaborators and published papers on the genetic basis of retinal vessel caliber, retinopathy, and age-related macular degeneration. For more information on the AGES study (design, progress and findings), see http://www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers. See also ZIAAG007380 and ZIAG006000(Dr. Harris).

在AGES队列中，我们能够评估健康，疾病和身体功能的各种概况。关于眼睛，我们正在评估眼病的患病率和风险因素，并调查在其他器官系统（包括大脑）中表现出疾病临床体征的人的可能功能相关性。 例如，AGES数据证实，视网膜病变见于未患糖尿病的老年人;未患糖尿病的人的病变占视网膜病变病例的大多数（78%）。 视网膜病变通常是轻微的。 肾功能障碍也可能存在于受影响的个体中。 AGES是基因组流行病学心脏和衰老研究队列（CHARGE）联盟的成员。因此，它参与遗传荟萃分析，用于发现或复制疾病的遗传变异。 AGES与国际合作者合作，发表了关于视网膜血管口径、视网膜病变和年龄相关性黄斑变性的遗传基础的论文。 有关AGES研究（设计、进展和发现）的更多信息，请访问http://www.hjarta.is/english/ages。参考研究网站上的项目参考书目以获取已发表的论文。 另见ZIAAG 007380和ZIAG 006000（Harris博士）。