Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

NIH对年龄的资助承诺研究于2017年结束，尽管对NIH投资所实现的数据分析在2019年仍在继续，以产生更多的新出版物，并获得关键的见解。 在年龄队列中，我们已经能够评估健康、疾病和身体功能的各种概况，并研究各种因素如何相互作用影响老年的生存和生活质量。 关于眼病的患病率和风险因素，以及其他描述在包括大脑在内的其他器官系统表现出临床疾病症状的人中视力受损的功能相关性的文献，已经发表了许多手稿。例如，AGEs数据证实，在没有糖尿病的老年人中发现了视网膜病变；没有糖尿病的人的病变占视网膜病变病例的大多数(78%)。通常情况下，视网膜损伤是轻微的。患有眼病的人也可能出现肾功能障碍。 AGES是基因组流行病学心脏和衰老研究(CHARD)联盟的成员，一直参与发现或复制各种疾病和条件的遗传变异的遗传荟萃分析。AGEs与国际合作者合作，发表了关于视网膜血管口径、视网膜病变和年龄相关性黄斑变性的遗传基础的论文。 AGES仍然是几个跨国研究财团的积极合作伙伴，包括欧盟委员会资助的赠款(613977)，通过生命周期优化维生素D营养和健康的基于食品的解决方案(odin；www.odin-vitd.eu)项目，该项目在美国国立卫生研究院领导的国际维生素D标准化计划的基础上对25(OH)D值进行标准化，并研究维生素D水平对整个欧洲大陆人口健康的流行度和影响。 有关AGES研究(设计、进展、发现和协作机会)的更多信息，请访问http://www.hjarta.is/english/ages.参考研究网站上的项目参考书目，以及在PubMed上发表的其他论文。 另见ZIAAG007380和ZIAG006000(Harris博士)。

The NIH funding commitment to the AGES study ended in 2017, although the analysis of data made possible by the NIH investment continues in 2019 to result in additional new publications and to reap critical insights. In the AGES cohort we have been able to assess various profiles of health, disease, and physical function and study how the interplay of factors influences survival and quality of life in old age. There have been numerous published manuscripts on the prevalence and risk factors of eye disease as well as others describing the functional correlates of impaired sight in persons exhibiting clinical signs of disease in other organ systems, including the brain. For example, AGES data confirms that retinopathy lesions are found in older people who do not have diabetes; lesions in persons without diabetes constitute the majority (78%) of retinopathy cases. Usually the retinal lesions are mild. Kidney dysfunction is also likely to be present in individuals with eye disease. AGES, a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, has been involved in genetic meta-analysis for discovery or replication of genetic variants of a variety of diseases and conditions. AGES has partnered with international collaborators and published papers on the genetic basis of retinal vessel caliber, retinopathy, and age-related macular degeneration. AGES remains an active collaborator in several multinational research consortia, including the European Commission-funded grant (613977), Food-based solutions for optimal Vitamin D nutrition and health through the life cycle (ODIN; www.odin-vitd.eu) project, which standardized 25(OH)D values building on the NIH-led international Vitamin D standardization program and studies the prevalence and impact of Vitamin D levels on health of populations across the European continent. For more information on the AGES study (design, progress, findings, and opportunities to collaborate), see http://www.hjarta.is/english/ages. Refer to project bibliography on the study website for additional published papers, as well as in PubMed. See also ZIAAG007380 and ZIAG006000(Dr. Harris).