Multi-ethnic Study Of Atherosclerosis - Vision Component

动脉粥样硬化的多种族研究 - 视觉成分

• 批准号: 9362377
• 负责人: Mary Frances Cotch
• 金额: $ 15.74万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9362377
• 关键词: African American; Aging; Air Pollution; Ancillary Study; Asian Americans; Atherosclerosis; Biological; Candidate Disease Gene; Cardiovascular Diseases; Cardiovascular system; Caucasians; Cohort Studies; Collaborations; Communities; Contracts; DNA; Data; Data Analyses; Deposition; Diabetic Retinopathy; Disease; Epidemiology; Ethnic Origin; Event; Eye; Family; Family Study; Family member; Funding; Fundus photography; Genes; Genetic; Genome Scan; Genomics; Genotype; Grant; Health; Hispanic Americans; Hispanics; Image; Individual; Institution; Intramural Research Program; Laboratories; Lung; Macular degeneration; Manuscripts; Measures; Medical center; Meta-Analysis; Methodology; Microvascular Dysfunction; National Heart, Lung, and Blood Institute; Parents; Participant; Pathology; Peer Review; Phenotype; Photography; Predictive Factor; Preparation; Principal Investigator; Protocols documentation; Publications; Publishing; Reading; Research; Research Personnel; Resources; Retinal; Role; Sampling; Severities; Siblings; Systemic disease; Testing; Time; Ultrasonography; Variant; Vision; Visit; Visual; Visual Acuity; Visual impairment; Woman; X-Ray Computed Tomography; aged; base; clinical phenotype; cohort; database of Genotypes and Phenotypes; design; digital; genetic analysis; genetic association; genetic linkage analysis; genome-wide; high risk; imaging modality; indexing; international partnership; member; men; novel; population based; sex; trait

The MESA study is on-going. MESA study visit five began in April 2010 and was completed in early 2012. Participants are currently being followed for health events. Analyses of various ocular phenotypes, including retinal microvascular disease, have resulted in multiple published manuscripts with more under preparation. Genotype and ocular phenotype data began to be released on dbGaP in August 2010. Genetic analyses under the auspices of MESA SHARe, CHARGE, and the BioProject are on-going. MESA has numerous ancillary studies, including a lung component (funded by NHLBI) and an air pollution component (funded by the EPA), allowing all investigators to leverage modest resources for maximal scientific advantage. Discussions to integrate and analyze data across various study components have resulted in several multi-disciplinary collaborations producing numerous peer-reviewed scientific publications, many of which are novel and would likely have been considered too high-risk to have ever received funding on their own. More information about the MESA Study and its ancillary studies, including a full list of participating investigators and institutions and a complete, up-to-date list of publications, can be found at http://www.mesa-nhlbi.org. For information on how to access MESA data, refer to dbGaP (http://www.ncbi.nlm.nih.gov/gap).

MESA 研究正在进行中。 MESA 第五次研究访问于 2010 年 4 月开始，并于 2012 年初完成。目前正在跟踪参与者的健康事件。 对各种眼部表型（包括视网膜微血管疾病）的分析已发表多篇手稿，更多手稿正在准备中。基因型和眼部表型数据于 2010 年 8 月开始在 dbGaP 上发布。在 MESA SHARe、CHARGE 和 BioProject 的支持下正在进行遗传分析。 MESA 拥有众多辅助研究，包括肺脏部分（由 NHLBI 资助）和空气污染部分（由 EPA 资助），使所有研究人员能够利用有限的资源获得最大的科学优势。 对整合和分析各个研究组成部分的数据的讨论导致了一些多学科合作，产生了大量经过同行评审的科学出版物，其中许多都是新颖的，可能被认为风险太高，无法单独获得资助。 有关 MESA 研究及其辅助研究的更多信息，包括参与研究人员和机构的完整列表以及完整的最新出版物列表，请访问 http://www.mesa-nhlbi.org。有关如何访问 MESA 数据的信息，请参阅 dbGaP (http://www.ncbi.nlm.nih.gov/gap)。