Atherosclerosis Risk in Communities - Retinal component

我们调查了981名中年ARIC研究参与者的视网膜病变的发病率和患病率，这些参与者被选择参加第三和第四次ARIC研究检查，并在两次研究访视时拍摄了同一只眼睛的视网膜照片。 视网膜病变的患病率为7.7%，其中3.8%的人在两次检查之间的三年内出现视网膜病变的迹象。 虽然糖尿病患者的视网膜病变发生率较高（147例中有40例），但非糖尿病患者的视网膜病变发生率相当（834例中有36例）。 增加视网膜病变风险的因素包括高血压、空腹血糖、总胆固醇和血浆纤维蛋白原水平。 我们检查了ARIC参与者样本中视网膜微血管病变的10年变化，发现在十年内，新的视网膜血管出现，并且很大一部分消失，这表明视网膜微血管发生了相当大的重塑。 有关该研究的更多信息，包括研究者和参与机构的完整列表以及最终出版物，请参见http://www.cscc.unc.edu/carmri/ 眼部表型与基因型数据的数据分析正在进行中。 这项研究的结果正在与参与CHARGE联盟的其他老龄化和心血管队列的结果合并，以增加检测疾病遗传信号的能力。 参见PLOS Genetics 2010年10月e1001184。 基于PLOS Genetics论文中报告的发现，ARIC和CHS参与者样本的测序正在进行中，预计将于2011年完成（作为Eric Boerwinkle博士指导下更大努力的一部分）。

We investigated the incidence and prevalence of retinopathy in a sample of 981 middle-aged ARIC study participants who were selected to participate in the third and fourth ARIC study examinations and who had retinal photographs of the same eye taken at both study visits. The prevalence of retinopathy was 7.7%, with 3.8% of people developing signs of retinopathy in the three year interval between exams. Although the rate of retinopathy was found to be higher among diabetics (40 of 147), a comparable number of cases occurred in non-diabetic individuals (36 of 834). Factors found to increase risk of retinopathy include higher levels of blood pressure, fasting serum glucose, total cholesterol, and plasma fibrinogen. We examined 10 year changed in retinal microvascular lesions in a sample of ARIC participants and found that, over a decade, new retinal vessels appeared and a significant proportion disappeared, suggesting considerable remodeling in the retinal microvasculature. For more information about the study, including the full list of investigators and participating institutions and resulting publications, see http://www.cscc.unc.edu/carmri/ Data analysis of ocular phenotypes in conjunction with genotype data is on-going. Findings from this study are being merged with those from other aging and cardiovascular cohorts participating in the CHARGE Consortium to allow for increased power to detect genetic signals of disease. See PLOS Genetics Oct 2010 e1001184. Building on findings reported in the PLOS Genetics paper, sequencing of a sample of ARIC and CHS participants is on-going with expected completion in 2011 (as part of a larger effort under the direction of Dr. Eric Boerwinkle).