Atherosclerosis Risk in Communities - Retinal component

社区动脉粥样硬化风险 - 视网膜成分

• 批准号: 8339777
• 负责人: Mary Frances Cotch
• 金额: $ 0.33万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8339777
• 关键词: Aging; Arterioloscleroses; Atherosclerosis; Blood Pressure; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Caring; Cholesterol; Clinical; Communities; Contracts; DNA; Data; Data Analyses; Disease; Epidemiologic Studies; Etiology; Event; Eye; Fasting; Fibrinogen; Funding; Gender; Genetic; Genomics; Genotype; Glucose; Goals; Grant; Health Status; Incidence; Individual; Institution; Lesion; Location; Measures; Medical; Metabolic; Methodology; National Heart, Lung, and Blood Institute; Natural History; Paper; Participant; Pathologic; Phenotype; Plasma; Platelet Activation; Platelet aggregation; Population; Prevalence; Publications; Race; Recruitment Activity; Reporting; Research Personnel; Retina; Retinal; Retinal Diseases; Risk; Sampling; Serum; Signal Transduction; Telephone; Time; Tissues; Variant; Visit; aged; cardiovascular risk factor; cohort; design; diabetic; field study; follow-up; middle age; monocyte; non-diabetic; novel; prospective; retina blood vessel structure; social

We investigated the incidence and prevalence of retinopathy in a sample of 981 middle-aged ARIC study participants who were selected to participate in the third and fourth ARIC study examinations and who had retinal photographs of the same eye taken at both study visits. The prevalence of retinopathy was 7.7%, with 3.8% of people developing signs of retinopathy in the three year interval between exams. Although the rate of retinopathy was found to be higher among diabetics (40 of 147), a comparable number of cases occurred in non-diabetic individuals (36 of 834). Factors found to increase risk of retinopathy include higher levels of blood pressure, fasting serum glucose, total cholesterol, and plasma fibrinogen. We examined 10 year changed in retinal microvascular lesions in a sample of ARIC participants and found that, over a decade, new retinal vessels appeared and a significant proportion disappeared, suggesting considerable remodeling in the retinal microvasculature. For more information about the study, including the full list of investigators and participating institutions and resulting publications, see http://www.cscc.unc.edu/carmri/ Data analysis of ocular phenotypes in conjunction with genotype data is on-going. Findings from this study are being merged with those from other aging and cardiovascular cohorts participating in the CHARGE Consortium to allow for increased power to detect genetic signals of disease. See PLOS Genetics Oct 2010 e1001184. Building on findings reported in the PLOS Genetics paper, sequencing of a sample of ARIC and CHS participants is on-going with expected completion in 2011 (as part of a larger effort under the direction of Dr. Eric Boerwinkle).

我们调查了981名中年ARIC研究参与者的视网膜病变的发生率和患病率，这些人被选为参加第三次和第四次ARIC研究检查的人，他们在两次研究访问中都拍摄了同一只眼睛的视网膜照片。视网膜病变的患病率为7.7%，3.8%的人在两次考试之间的三年内出现视网膜病变的迹象。虽然糖尿病患者中视网膜病变的发生率较高(147例中有40例)，但非糖尿病患者中也有类似数量的病例(834例中有36例)。发现增加视网膜病变风险的因素包括较高的血压、空腹血糖、总胆固醇和血浆纤维蛋白原水平。 我们研究了ARIC参与者样本中10年来视网膜微血管病变的变化，发现在过去的10年里，新的视网膜血管出现，相当一部分消失，这表明视网膜微血管系统发生了相当大的重塑。 有关这项研究的更多信息，包括研究人员和参与机构的完整名单以及由此产生的出版物，请访问http://www.cscc.unc.edu/carmri/。 结合基因数据对眼部表型的数据分析正在进行中。这项研究的结果正在与参与Charge Consortium的其他老龄化和心血管队列的研究结果合并，以允许增加检测疾病遗传信号的能力。参见PLOS Genetics 2010年10月e1001184。 在《公共科学图书馆·遗传学》论文报告的基础上，对ARIC和CHS参与者样本的测序工作正在进行中，预计将于2011年完成(这是Eric Boerwinkle博士指导下的更大努力的一部分)。