MESA Family - Ocular Component

2004年5月开始为梅萨家庭招募非洲裔美国人和西班牙裔兄弟姐妹。到2006年底，当登记工作完成时，共有来自608个家庭的3026艘船舶登记。 在这个MESA家族样本上，候选基因的表型注释和基因分型已经完成。候选基因分析的初步结果表明，之前还需要进一步的基因分型，这一活动一直在进行中。 对MESA指数病例的一个子样本(来自原始MESA队列)的遗传分析也表明，需要在整个MESA队列上采取全基因组战略。2009年为这项活动提供了资金。 有关MESA研究及其附属项目(如MESA家庭)的更多信息，包括合作者和参与机构的名单，请参阅http://www.mesa-nhlbi.org.

Recruitment of African American and Hispanic sibships for MESA Family began in May 2004. By the end of 2006, when enrolled was complete, 3026 shipships from 608 families were enrolled. On this MESA Family sample, phenotype annotation and genotyping of candidate genes has been completed. Preliminary results from candidate genes analyses indicated that further genotyping would be required before, and this activity has been on-going. Genetic analyses on a subsample of MESA index cases (from the original MESA cohort) also indicated that genome-wide strategies would be required on the entire MESA cohort. Funding for this activity was provided in 2009. For additional information about the MESA study and projects ancillary to it such as MESA Family, including a list of collaborators and participating institutions, see http://www.mesa-nhlbi.org.