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Risk for Child Psychopathology: A Twin-Study Perspective

儿童精神病理学的风险：双胞胎研究的视角

基本信息

批准号：
8223508
负责人：
Harold Hill Goldsmith
金额：
$ 13.66万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-12-10 至 2013-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8223508
关键词：
12 year old 2 year old Adolescent Affect Affective Age Anger Anxiety Architecture Attention Attention deficit hyperactivity disorder Behavior Behavioral Biological Biometry Birth Records Candidate Disease Gene Caregivers Child Child Mental Health Childhood Classification Clinical Cognitive Comorbidity Computers Conduct Disorder Conflict (Psychology)Control Groups DSM-IV Decision Making Depressed mood Development Diagnosis Diagnostic Dimensions Discipline Disease Early Diagnosis Environment Environmental Risk Factor Epidemiology Etiology Event Factor Analysis Family Family history of Family member Foundations Fright Future Genetic Genetic Techniques Growth Heterogeneity Home environment Hormones Hydrocortisone Individual Informal Social Control Intervention Interview Investigation Knowledge Life Link Measurement Measures Mediating Medical Records Mental Depression Mental Health Methodology Modeling Nature Only Child Outcome Parenting behavior Parents Patient Self-Report Pattern Prevention program Process Protocols documentation Psychopathology Qualifying Quantitative Genetics Questionnaires Reaction Time Recovery Recruitment Activity Regulation Relative (related person)Reporting Research Methodology Resources Risk Risk Factors Role Sampling Schools Science Screening procedure Sensory Social Interaction Social Problems Source Specific qualifier value Stress Structure Symptoms Temperament Testing Testosterone Time Translations Twin Multiple Birth Twin Studies Videotape base biopsychosocial clinical practice dehydroepiandrosterone design endophenotype experience follow-up genetic analysis improved indexing interest intervention program longitudinal design maternal depression psychosocial public health relevance skills socioeconomics theories trait

项目摘要

DESCRIPTION (provided by applicant): Using the resources of an epidemiologically defined, longitudinal twin study, we examine developmental course and biopsychosocial risks for childhood psychopathology. Building on existing screening at ages 2 and 7 years, we characterize risk factors at ages 2, 7, and 12 relevant to the development of internalizing (anxiety and depression), externalizing (oppositional and conduct disorder), and ADHD. Most of our at-risk cases qualify for a DSM-IV diagnosis, yet we include individuals with sub-threshold symptoms and a large control group. Specific aims include characterization of risk factors, analysis of genetic and environmental effects, and improved measurement and classification of childhood disorders. "Child-based" risk factors include earlier symptoms, temperament and stress reactivity, basal and reactive cortisol, testosterone and DHEA, cognitive abilities and attributional styles, and cognitive-affective processing skills. Family and other psychosocial risk factors include parental diagnosis and family history of psychopathology, twin-twin and twin-parent social interaction styles, multiple facets of family stress, and negative parenting. The research methods that we employ include structured diagnostic interviews with caregivers and children, medical records, observer ratings, child self-report and parent-report questionnaires, videotaped home-based behavioral batteries, and computer-based testing (mostly reaction time tasks). The study's significance lies in understanding how known risk factors interact and/or mediate each other's effects on child psychopathology in a genetically informative, longitudinal design. Twin methodology allows us to parse phenotypic variance and covariance among measures into genetic and environmental components, and the components are studied developmentally. The results should also enhance our understanding of comorbidity, heterogeneity within disorders, and the association of disorders with traits. The project's public health relevance lies in its identification of risk factors for common childhood disorders and its investigation of how they interact in the context of genetic and environmental factors. The knowledge gained should inform efforts toward early detection, improved interventions, and better classification of childhood disorders.

描述（由申请人提供）：利用流行病学定义的纵向双胞胎研究的资源，我们研究了儿童精神病理学的发育过程和生物心理社会风险。在现有的2岁和7岁筛查的基础上，我们描述了2岁、7岁和12岁时与内化（焦虑和抑郁）、外化（对立和行为障碍）和多动症发展相关的风险因素。我们的大多数高危病例符合DSM-IV的诊断，但我们包括了亚阈值症状的个体和一个大的对照组。具体目标包括确定风险因素，分析遗传和环境影响，以及改进儿童疾病的测量和分类。“以儿童为基础”的风险因素包括早期症状、气质和应激反应、基础和反应性皮质醇、睾酮和脱氢表雄酮、认知能力和归因方式，以及认知情感处理技能。家庭和其他社会心理风险因素包括父母诊断和精神病理学家族史、双胞胎和双胞胎的社会互动方式、家庭压力的多个方面以及消极的养育方式。我们采用的研究方法包括对照顾者和儿童的结构化诊断访谈、医疗记录、观察者评分、儿童自我报告和父母报告问卷、家庭行为录像以及基于计算机的测试（主要是反应时间任务）。这项研究的意义在于了解已知的风险因素如何在遗传信息丰富的纵向设计中相互作用和/或调解彼此对儿童精神病理的影响。双胞胎方法使我们能够将表型变异和协方差分析为遗传和环境成分，并对这些成分进行发育研究。研究结果也应该增强我们对疾病的合并症、异质性以及疾病与特征的关联的理解。该项目的公共卫生相关性在于确定常见儿童疾病的风险因素，并调查它们如何在遗传和环境因素的背景下相互作用。所获得的知识应该为早期发现、改进干预措施和更好地分类儿童疾病提供信息。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Partial replication of two rumination-related candidate gene studies.

两项与沉思相关的候选基因研究的部分复制。

DOI：
10.1080/02699931.2016.1168779
发表时间：
2017
期刊：
Cognition & emotion
影响因子：
2.6
作者：
VanHulle,CarolA;Clifford,Sierra;Moore,MollieN;Lemery-Chalfant,Kathryn;Goldsmith,HHill
通讯作者：
Goldsmith,HHill

Genetic variance for autism screening items in an unselected sample of toddler-age twins.

未经选择的幼儿双胞胎样本中自闭症筛查项目的遗传方差。

DOI：
10.1016/j.jaac.2009.11.012
发表时间：
2010
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry
影响因子：
13.3
作者：
Stilp,RebeccaLH;Gernsbacher,MortonAnn;Schweigert,EmilyK;Arneson,CarrieL;Goldsmith,HillH
通讯作者：
Goldsmith,HillH

Genetic Relations Between Effortful and Attentional Control and Symptoms of Psychopathology in Middle Childhood.

努力和注意力控制与童年中期精神病理学症状之间的遗传关系。