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Molecular Cell Biology of Macrophages in Human Diseases

人类疾病中巨噬细胞的分子细胞生物学

基本信息

批准号：
8641516
负责人：
DAVID L. WOODLAND
金额：
$ 0.7万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-01 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8641516
关键词：
Animal Model Area Benchmarking Biology Cardiovascular system Cells Collaborations Development Developmental Biology Disease Drosophila genus Educational workshop Epigenetic Process Fostering Genetic Genetic Heterogeneity Glass Health Heterogeneity Homeostasis Human Human Genetics Immune response Immunologist Infectious Disease Immunology Inflammatory Interdisciplinary Study International Learning Macrophage Cell Biology Malignant Neoplasms Maps Metabolism Methods Molecular Molecular Biology Molecular Genetics Mus New Mexico Outcome Patients Play Research Research Personnel Role Scientist Students Tissues Training Work Zebrafish abstracting base cancer cell cell motility clinical phenotype human disease in vivo in vivo Model interdisciplinary approach interest intravital imaging macrophage meetings next generation novel novel therapeutic intervention public health relevance repaired symposium

项目摘要

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Molecular Cell Biology of Macrophages in Human Diseases, organized by Frederic Geissmann, Judith E. Allen and Christopher K. Glass. The meeting will be held in Santa Fe, New Mexico from February 9-14, 2014. In recent years, studies of the development, genetics, and molecular cell biology of macrophages have advanced our understanding of their major role in health and diseases. Many questions remain to be answered with respect to mechanisms that control macrophage development and function, particularly in the context of human genetic heterogeneity. Recent discoveries have also revealed greater heterogeneity in macrophage function and origins than previously appreciated. Answering these questions will have major implications for human health and disease. To help meet this challenge, the Keystone Symposia meeting on Molecular Cell Biology of Macrophages in Human Diseases will bring together leading and upcoming scientists in immunology, infectious diseases, metabolism, molecular biology and genetics, development, cancer, and cell migration with a common interest in macrophages and their roles in human diseases. In addition to the regular sessions, three workshops will provide a platform to discuss the findings of junior scientists (selected from the submitted abstracts). These workshops will additionally help to focus the meeting on some of the fastest moving areas of macrophage biology.

概述（由申请人提供）：现申请支持由Frederic Geissmann， Judith E. Allen和Christopher K. Glass组织的题为“巨噬细胞在人类疾病中的分子细胞生物学”的Keystone专题会议。会议将于2014年2月9日至14日在新墨西哥州圣达菲举行。近年来，对巨噬细胞的发育、遗传学和分子细胞生物学的研究使我们对巨噬细胞在健康和疾病中的主要作用有了更深入的了解。关于控制巨噬细胞发育和功能的机制，特别是在人类遗传异质性的背景下，仍有许多问题有待回答。最近的发现也揭示了巨噬细胞功能和起源的更大异质性。回答这些问题将对人类健康和疾病产生重大影响。为了应对这一挑战，巨噬细胞在人类疾病中的分子细胞生物学专题讨论会将汇集免疫学、传染病、代谢、分子生物学和遗传学、发育、癌症和细胞迁移领域的领先和未来的科学家，他们对巨噬细胞及其在人类疾病中的作用有共同的兴趣。除了定期会议之外，三个研讨会将提供一个平台来讨论初级科学家（从提交的摘要中选出）的发现。这些研讨会还将有助于将会议重点放在巨噬细胞生物学中一些发展最快的领域。