T and B Cell Collaboration in Germinal Centers and Beyond

摘要 请求为题为“德国T和B细胞协作”的Keystone专题讨论会提供支助 中心和超越，由博士谢恩克罗蒂，米歇尔Locci和詹妮弗Gommerman组织。会议 将于2023年10月1日至4日在加拿大不列颠哥伦比亚省惠斯勒举行。 T细胞/B细胞相互作用是许多免疫应答的基础。随着2019冠状病毒病大流行 证明，COVID-19疫苗的成功开发突出了T和B细胞的极端价值， 保护性免疫的相互作用。例如，开发能够中和变体的抗体， 与Omicron不同，在不是一次或两次而是三次其他mRNA免疫后， SARS-CoV-2 Spike是一个戏剧性的例子，说明了生殖中心在保护性免疫中的重要性， 免疫系统在快速进化的T依赖性B细胞反应中的卓越表现， 病毒变异细胞以前从未在生殖中心遇到过。然而，仍有许多工作要做。 了解T细胞/B细胞相互作用和疫苗的生殖中心的至关重要性， 传染病此外，这些免疫相互作用的相关性在以下方面要广泛得多： 生物医药T细胞/B细胞相互作用在许多自身免疫性疾病中是重要的。此外，本次会议 将与“B细胞和第三类乳突状结构：新兴靶点”的基石研讨会联合举行 在癌症治疗，并将有联合会议涵盖T细胞/B细胞在癌症中的相互作用。

ABSTRACT Support is requested for a Keystone Symposia conference entitled T and B Cell Collaboration in Germinal Centers and Beyond, organized by Drs. Shane Crotty, Michela Locci and Jennifer Gommerman. The conference will be held in Whistler, British Columbia, Canada from October 1-4, 2023. T cell/B cell interactions are fundamental for numerous immune responses. And, as the COVID-19 pandemic demonstrated, the successful development of COVID-19 vaccines highlighted the extreme value of T and B cell interactions for protective immunity. For example, the development of antibodies able to neutralize variants as diverse as Omicron, after not one or two but after three other mRNA immunizations, with the same ancestral SARS-CoV-2 Spike, is a dramatic example of the importance of germinal centers in protective immunity, and the brilliance of the immune system in rapidly evolving T-dependent B cell responses capable of neutralizing extreme viral variants the cells never previously encountered in the germinal centers. However, there remains much to be learned about the critical importance of T cell/B cell interactions and germinal centers for vaccines and infectious diseases. Furthermore, the relevance of these immunological interactions is much broader in biomedicine. T cell/B cell interactions are important in many autoimmune diseases. Moreover, this conference will be held jointly with the Keystone Symposium on B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics and there will be joint sessions covering T cell/B cell interactions in cancer.