T and B Cell Collaboration in Germinal Centers and Beyond

摘要 请求支助题为生发中T和B细胞协作的Keystone研讨会会议 中心和更远的地方，由Shane Crotty博士、Michela Locci博士和Jennifer Gommerman组织。这次会议 将于2023年10月1日至4日在加拿大不列颠哥伦比亚省惠斯勒举行。 T细胞/B细胞的相互作用是许多免疫反应的基础。而且，随着新冠肺炎大流行 实践证明，新冠肺炎疫苗的成功研制凸显了T、B细胞的极值 保护性免疫的相互作用。例如，能够中和变异体的抗体的开发 在不是一次或两次而是三次其他mRNA免疫后，具有相同的祖先，与Omicron一样多样化 SARS-CoV-2尖峰病毒是生发中心在保护性免疫中重要性的一个戏剧性例子，以及 免疫系统在快速进化的T依赖B细胞反应中的光辉能够中和极端 细胞以前从未在生发中心遇到过的病毒变体。然而，还有很多事情要做 了解T细胞/B细胞相互作用和生发中心对疫苗和 传染病。此外，这些免疫学相互作用的相关性在 生物医学。T细胞/B细胞相互作用在许多自身免疫性疾病中起着重要作用。另外，这次会议， 将与B细胞和第三级淋巴结构：新兴目标的Keystone研讨会联合举行 在癌症治疗方面，将有关于癌症中T细胞/B细胞相互作用的联合会议。

ABSTRACT Support is requested for a Keystone Symposia conference entitled T and B Cell Collaboration in Germinal Centers and Beyond, organized by Drs. Shane Crotty, Michela Locci and Jennifer Gommerman. The conference will be held in Whistler, British Columbia, Canada from October 1-4, 2023. T cell/B cell interactions are fundamental for numerous immune responses. And, as the COVID-19 pandemic demonstrated, the successful development of COVID-19 vaccines highlighted the extreme value of T and B cell interactions for protective immunity. For example, the development of antibodies able to neutralize variants as diverse as Omicron, after not one or two but after three other mRNA immunizations, with the same ancestral SARS-CoV-2 Spike, is a dramatic example of the importance of germinal centers in protective immunity, and the brilliance of the immune system in rapidly evolving T-dependent B cell responses capable of neutralizing extreme viral variants the cells never previously encountered in the germinal centers. However, there remains much to be learned about the critical importance of T cell/B cell interactions and germinal centers for vaccines and infectious diseases. Furthermore, the relevance of these immunological interactions is much broader in biomedicine. T cell/B cell interactions are important in many autoimmune diseases. Moreover, this conference will be held jointly with the Keystone Symposium on B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics and there will be joint sessions covering T cell/B cell interactions in cancer.