New Paradigms in Cancer Therapeutics

描述（由申请人提供）：本提案请求支持由Arul M. Chinnaiyan和William R. Sellers组织的题为“癌症治疗新范式”的Keystone专题会议，该会议将于2010年3月23日至28日在加拿大不列颠哥伦比亚省举行。基因组规模分析技术的出现为全面监测癌症中多层分子畸变提供了可能性。表观基因组、基因组、转录组、蛋白质组和代谢组的改变都在肿瘤的发展过程中被观察到。在癌症进展过程中，一些关键的分子通路被发现发生了改变。该领域的关键问题包括：这些新途径单独或联合起来能有效靶向治疗癌症吗？我们能识别分子特征来促进个性化医疗吗？有哪些创新的治疗方式可以针对这些途径？

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled New Paradigms in Cancer Therapeutics, organized by Arul M. Chinnaiyan and William R. Sellers, which will be held in British Columbia, Canada from March 23 - 28, 2010. The advent of genome-scale profiling technologies has opened up the possibility of comprehensively monitoring multiple layers of molecular aberrations in cancer. Alterations in the epigenome, genome, transcriptome, proteome and metabolome have all been observed in tumor development. A number of key molecular pathways have been found to be altered during cancer progression. Pivotal questions in the field include: Can these novel pathways alone or in combination be effectively targeted in cancer? Can we identify molecular signatures that will facilitate personalized medicine? What are the innovative therapeutic modalities that can be employed to target these pathways? The goal of this meeting is to tackle promising new targets for cancer therapy. These include targets such as recurrent gene fusions, epigenetic pathways, and metabolic networks. We will also explore the use of molecular marker panels to select patients for treatment. A number of approaches to therapeutic targeting will be discussed including novel biologics and RNA interference. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Integration of Developmental Signaling Pathways which will share a keynote address and a plenary session with this meeting.