HIGH MASS-TO-CHARGE FOURIER TRANSFORM MASS SPECTROMETRY

高质荷傅里叶变换质谱

• 批准号: 8168670
• 负责人: MICHAEL L GROSS
• 金额: $ 1.75万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168670
• 关键词: Cells; Charge; Computer Retrieval of Information on Scientific Projects Database; Detection; Effectiveness; Fourier Transform; Funding; Goals; Grant; Institution; Ions; Mass Spectrum Analysis; Motion; Peptides; Proteins; Proteomics; Research; Research Personnel; Research Project Grants; Resources; Source; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Testing; United States National Institutes of Health; electrical property; improved; instrumentation; interest; magnetic field

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purposes of the research are to understand ion motion in modified FTMS traps, to construct traps guided by the theoretical considerations, and to test the effectiveness of the electrically compensated cell to study high-mass ions generated by MALDI. The goal of this core research project is to improve the detection for biomolecule ions with mass-to-charge ratios greater than a few thousand by making changes to the electrical properties of the trap rather than by increasing the magnetic field strength. We suggest that the instrumentation will not only be of interest for mid-sized proteins but also for peptides in proteomics applications.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究的目的是了解离子运动的修改FTMS陷阱，构建陷阱的理论考虑的指导下，并测试的有效性的电补偿细胞研究MALDI产生的高质量离子。 该核心研究项目的目标是通过改变陷阱的电特性而不是通过增加磁场强度来改善对质荷比大于几千的生物分子离子的检测。 我们建议，仪器将不仅是中型蛋白质的兴趣，但也为肽在蛋白质组学应用。