Hematopoiesis

摘要 要求为Catriona博士组织的题为造血的Keystone专题讨论会提供支助 H.M.放大图片作者：Jamieson，Andreas Trumpp，Paul S.弗蕾内特会议将在加拿大阿尔伯塔省班夫市举行 2017年1月31日至2月4日。自从发现造血可以通过一个单一的 细胞五十多年前，模型系统，测序，重编程和基因组编辑的进展 技术使得能够精确地对造血调节剂进行分子表征。这些 这些发现为广泛的良性和恶性肿瘤的临床试验提供了信息， 恶性血液系统疾病，包括骨髓衰竭综合征和白血病，以及指导 发展分子生物学策略。这次会议将汇集基本的， 和临床研究人员讨论造血干细胞和祖细胞个体发育，细胞命运的关键调节因子， 在体内平衡、压力和恶性转化过程中的规范和自我更新。的相对 细胞自主遗传、表观遗传、转录和转录后造血重要性 国际领导人将介绍监管机制以及当地的利基或系统因素， 造血和干细胞生物学领域。创新基因组编辑的高潮， 在不同的模型系统中进行重编程、单细胞测序和成像，以揭示重要的调节因子 血细胞生成的重要性。我们预计，这次会议将提供一个重要机会， 来自不同学科的研究人员之间的合作，并从大量的 模型系统，使研究人员能够解决基础，转化和临床造血研究 挑战

ABSTRACT Support is requested for a Keystone Symposia meeting entitled Hematopoiesis, organized by Drs. Catriona H.M. Jamieson, Andreas Trumpp and Paul S. Frenette. The meeting will be held in Banff, Alberta, Canada from January 31 – February 4, 2017. Since the discovery that hematopoiesis could be established by a single cell over five decades ago, advances in model systems, sequencing, reprogramming and genome editing technologies have enabled precise molecular characterization of regulators of hematopoiesis. These discoveries have informed and accelerated implementation of clinical trials for a broad of array of benign and malignant hematologic disorders, including bone marrow failure syndromes and leukemia, as well as guided the development of molecular prognostication strategies. This meeting will bring together basic, translational and clinical researchers to discuss key regulators of hematopoietic stem and progenitor cell ontogeny, cell fate specification and self-renewal during homeostasis, stress and malignant transformation. The relative importance of cell-autonomous genetic, epigenetic, transcriptional and post-transcriptional hematopoietic regulatory mechanisms as well as local niche or systemic factors will be presented by international leaders in the field of hematopoiesis and stem cell biology. The culmination of innovative genome editing, reprogramming, single-cell sequencing and imaging in different model systems to unravel essential regulators of hematopoiesis will be highlighted. We anticipate that this meeting will provide a vital opportunity for forging collaborations between researchers from disparate disciplines and result in novel insights from a plethora of model systems that will enable investigators to address basic, translational and clinical hematopoiesis research challenges.