Uncovering an evolutionary advanced mechanism of gene expression control

该项目旨在揭示一种激活哺乳动物基因表达的新机制，这种机制涉及染色体核心成分与基因表达所需的基本酶机器之间意想不到的联系。该项目将在人们知之甚少的过程中产生新的知识，即如何有选择地选择多细胞生物体的广泛基因组信息，使其能够仅表达所需的基因子集。这将彻底改变我们对基因控制机制的理解，从而塑造未来的领域。值得注意的是，这将允许新的方法来操纵基因表达，这将通过提供新的高效方法来生产蛋白质或RNA，从而影响生物技术。

This project aims to uncover a new mechanism that activates gene expression in mammals, which involves unexpected connections between the core components of chromosomes and essential enzymatic machines required for the expression of genes. This project will generate new knowledge on the poorly understood process of how the extensive genomic information of multicellular organisms is selectively chosen to enable the expression of only the required subset of genes. This will revolutionise our understanding of the mechanisms of gene control thereby shaping the field in the future. Significantly, this will allow new ways to manipulate gene expression that will impact biotechnology by providing new efficient ways to produce proteins or RNA.