Acquisition of A 500 MHz NMR Console

要求国家科学基金会提供资金，协助购买一个500兆赫核磁共振控制台和两个探头。所要求的控制台将取代现有的瓦里安VXR-500控制台（1987年制造），并将位于最近扩建的化学系仪器设施（DCIF）。增加一个现代化的500 MHz NMR控制台是一项重大举措的组成部分，其中包括一项540，000美元的翻新工程，该工程已在进行中，以升级和现代化马萨诸塞州理工学院的多用户DCIF。由一个500兆赫的核磁共振仪器提供的新功能，具有三个射频通道和脉冲场梯度，对于在该部门进行生物相关的研究至关重要。将从购置高场核磁共振仪器中受益的项目分为以下几大类：（1）药物-DNA相互作用的研究;（2）选择性抑制肿瘤细胞的药物设计;（3）对蛋白质螺旋性基础的化学理解的发展;以及（4）小蛋白质的核磁共振研究。 目前，DCIF中的两个500 MHz NMR控制台已经使用了10多年。缺乏现代化的高场核磁共振仪器，要求部门研究人员需要最先进的核磁共振技术，以获得在区域设施的时间，并对生产力产生负面影响。 500兆赫核磁共振控制台具有更高的灵敏度、更好的可调谐性、数字滤波、脉冲场梯度、选择性激发和三重共振，将极大地促进该部正在进行的生物研究。

Funds are requested from the NSF to assist in the purchase of a 500 MHz nuclear magnetic resonance (NMR) console and two probes. The requested console will replace an existing Varian VXR-500 console (made in 1987) and will be located in the recently expanded Department of Chemistry's Instrumentation Facility (DCIF). The addition of a modern 500 MHz NMR console is an integral part of a major initiative, including a $540,000 renovation, which is already underway to upgrade and modernize the multi-user DCIF at the Massachusetts Institute of Technology. The new capabilities provided by a 500 MHz NMR instrument with three rf channels and pulsed field gradients are vital for the carrying out of biologically-related research in the Department. Projects that will benefit from the acquisition of a high-field NMR instrument fall into the following general categories: (1) investigations of drug-DNA interactions; (2) design of drugs that selectively inactivate tumor cells; (3) development of a chemical understanding of the basis for helicity in proteins; and (4) NMR studies of small proteins. At present, the two 500 MHz NMR consoles in the DCIF are more than 10 years old. The lack of modern, high-field NMR instrumentation requires Departmental researchers with a need for state-of-the-art NMR technology to obtain time at regional facilities and negatively impacts productivity. Biological research being carried out in the Department would be greatly facilitated by a 500 MHz NMR console with increased sensitivity, better shims, digital filtering, pulsed-field gradients, selective excitation, and triple resonance.