Immediate loading of titanium implant achieved by nano surface modifications

本研究旨在通过表面修饰实现钛种植体的即时加载和长期临床成功。钛植入物的即时载荷很大程度上取决于其在骨腔中的机械稳定性。钛植入物应以适当的扭矩固定。因此，为防止改性表面脱落，表面改性应制备得尽可能薄。为防止涂层表面脱落，采用高导骨磷酸钙纳米颗粒对钛种植体表面进行修饰。该涂层表面在体内表现出良好的骨置换效果。另一方面，由于钛种植体不仅可以穿透牙龈，还可以穿透牙龈，因此需要对种植体表面进行修饰，以达到抗菌活性和骨导电性。我们证明了在NaC1溶液中阳极氧化后的钛表面具有很高的抗菌活性，并且具有良好的细胞相容性。可以认为，该技术有助于钛种植体的长期临床成功。这些新的表面修饰技术可能在进一步的临床阶段发挥关键作用。

This study aimed to achieve immediate loading as well as long-term clinical success of titanium implants by means of surface modifications. Immediate loading of titanium implants strongly depends on its mechanical stability in a bone cavity. Titanium implants should be fixed with an appropriate torque. Thus, to prevent detaching of modified surface, surface modifications should be prepared as thin as possible. To prevent detaching of coating surface, the surface of titanium implants were modified by high- osteoconductive calcium phosphate nano-particles. The coating surface demonstrated a favorable bone-replacement in vivo. On the other hand, since titanium implants penetrate not only one but also gingival, implant surface should be modified to achieve antibacterial activity as well as osteo coductivity. We demonstrated that titanium surface anodized by being discharged in NaC1 solution could achieve high antibacterial activity against oral bacteria as well as excellent cell-compatibility. It can be assumed that this technique well contribute in long-term clinical success of titanium implants. These newly surface modification techniques might have key role in further clinical stage.