Development of effective conservative combined therapy for malignant tumor using quantitative analysis for vascular structure

本研究从细胞水平和动物体内水平两个阶段进行，旨在开发有效的恶性肿瘤保守性综合治疗方法。放疗、化疗和热疗是目前临床上常用的综合治疗方法。在细胞水平上获得高治疗效果的联合疗法引起肿瘤周围血管的减少和破碎，并且其对小鼠恶性肿瘤显示出高治疗效果。此外，还建议我们能够显著降低每种治疗的处方剂量。

This study was conducted with two phases of cellular level and in vivo level using experimental animal, for the aim of development of effective conservative combined therapy for malignant tumor. Radiotherapy, chemotherapy and hyperthermia were chosen for the combined therapy, because those were commonly used clinically. The combined therapy that high treatment effect was obtained at a cellular level caused decrease and fragmentation of vascular around a tumor, and it showed high treatment effect for the malignant tumors of mice. Furthermore, it was suggested that we will be able to markedly decrease the prescription dose of each therapy.