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Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.

Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.
胰腺癌中外分泌祖基因表达与癌症干细胞的相关性。
批准号:
22591519
负责人:
WADA Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

WADA Hiroshi的其他基金

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相关文献

中文摘要
翻译
我们评估了胰腺癌外分泌祖细胞基因和肿瘤干细胞标记物的表达。CD44阳性细胞在术前放化疗(CRT)后富集。CRT后Pdx 1阳性肿瘤有局限于胰腺的趋势。Pdx 1与CD 44的表达无相关性。CD44阳性而不表达Pdx 1者预后差。这些结果表明,转染外分泌祖基因可能会降低胰腺癌的恶性行为。
英文摘要
We evaluated the expression of exocrine progenitor genes and cancerstem cells markers in pancreatic cancer. CD44-positive cells were enriched after preoperative chemo-radiation therapy (CRT). Pdx1 positive tumors tended to limit to pancreas after CRT. There was no correlation between expression of Pdx1 and CD44. CD44-positive tumors without expression of Pdx1 were poor prognosis. These results suggested that transfection of exocrine progenitor genes may decrease its malignant behavior in pancreatic cancer.
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会议论文
A case report of port-site metastasis of pancreatic cancer after laparoscope assistted distalpancreatectomy
腹腔镜辅助远端胰腺切除术后胰腺癌端口转移一例报告
DOI: --
发表时间: 2011
期刊: Gan To Kagaku Ryoho
影响因子: --
作者: [Koga C, Tanemura M, Wada H, Kobayashi S, Marubashi S, Eguchi H, Mori M, Doki Y, Nagano H]
通讯作者: Nagano H
DOI: 10.1038/onc.2011.59
发表时间: 2011-08-01
期刊: ONCOGENE
影响因子: 8
作者: [Akita, H., Nagano, H., Doki, Y.]
通讯作者: Doki, Y.
DOI: 10.5754/hge11392
发表时间: 2012-01-01
期刊: HEPATO-GASTROENTEROLOGY
影响因子: --
作者: [Eguchi, Hidetoshi, Tanemura, Masahiro, Nagano, Hiroaki]
通讯作者: Nagano, Hiroaki
A case report of total remnant pancreatectomy for ductal carcinoma after distal pancreatectomy for invasive intraductal papillary mucinous carcinoma
侵袭性导管内乳头状粘液癌远端胰腺切除术后全残胰切除术治疗导管癌一例报告
DOI: --
发表时间: 2012
期刊: Gan To Kagaku Ryoho
影响因子: --
作者: [Okubo K, Hama N, Kobayashi S, Eguchi H, Akita H, Wada H, Kawamoto K, Marubashi S, Tanemura M, Umeshita K, Mori M, Doki Y, Nagano H]
通讯作者: Nagano H
共 8 条
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    • 项目类别:
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    • 资助金额:
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    • 财政年份:
      2011
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    • 资助金额:
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    • 批准号:
      20390439
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.23万
    • 财政年份:
      2008
    • 负责人:
      WADA Hiroshi
    • 依托单位:
    海外基金